Center for Integrative Biology | U Mayor

Universidad Mayor Researcher detailed the main behaviors that would boost the onset of brain diseases

Rene Vidal Ruta Pensamiento

At the second conference of "The Route of Thought", PhD. René Vidal, researcher at the CIB (Center for Integrative Biology), called for a healthy diet and constant physical and intellectual activity. In addition, he explained that the use of probiotics could help prevent pathologies such as Alzheimer's or Parkinson's.

"The route of thought", which is the cycle of speeches with which the Direction Public Engagement is looking to bring scientific topics to the community, had its second conference this year. This time, the protagonist was PhD. René Vidal, researcher at the Center for Integrative Biology (CIB) Universidad Mayor, who explained about diseases that affect the brain.

During the presentation, the academic explained on details the changes that the brain suffers in a natural way as part of aging, detailing that over the years this organ loses density and connectivity between neural networks, a process that accelerates the pathological neurodegeneration, promoting diseases such as Alzheimer's and Parkinson's, for which there is currently no pharmacological cure.

However, researches indicate that other therapies that could contribute at the time of suffering.

-PhD. Vidal, what steps can be taken to prevent pathological neurodegeneration?

"Adopting sociocultural behaviors that promote a healthy life, such as maintaining a balanced diet in terms of the consumption of proteins, vegetables and carbohydrates; To have physical activity throughout our life, with the purpose that the cardiovascular system is active and the organism balanced in terms of nutrients and toxic substances to which we are exposed daily.

Another important issue is to avoid the use and abuse of drugs such as alcohol, cigarettes and marijuana, among others, that are damaging to our organism. In addition, it should be considered that stress in our lives affects us in an important way, especially for the development of diseases manifested in old age. "

What factors affect the early onset of these pathologies?

"The lack of intellectual and physical activity are factors that directly affect the normal functioning of the brain, and thus in the vulnerability of this to disease development".

Another point that PhD. Vidal highlighted in his speech held at the Centro Cultural Gabriela Mistral, are the various therapies used to try to confront the progress of these pathologies. Thus, he explained the difference between the so-called "gene" and "cellular" therapies.

"The gene type is aimed at changing the function of the cells subjected to treatment, either by increasing the expression of a beneficial gene or eliminating a gene that is the cause of the disease. On the other hand, cell therapy seeks to restore defective cells or that were eliminated from the organism resulting from the disease and thereby reverse the pathological process, "Vidal explains.

Probiotics use.

Meanwhile, consulted on the use of probiotics against the development of neurodegenerative diseases, he stated that "the evidence that exists nowadays has demonstrated that the vegetation of the microbiota that lives in the intestine changes in these diseases, whether in Alzheimer's, Parkinson's, dementia, and many other diseases that affect the brain. "

"That is one thing, the other is that it has also been demonstrated that the use of probiotics in experimental models, not in humans, reverses the neurodegeneration process. This has mainly to do with the phenomenon of inflammation, which is present in both the brain and the digestive system; Then the use of probiotics would modify the microbiota or all living organisms that live in our intestine. This modification would reduce the level of inflammation of the intestine and could also reduce inflammation in the brain, which would lead to an improvement in the symptoms, "he explains. –

What early symptoms could warn of the onset of neuronal deterioration?

" Nowadays the early diagnosis of these diseases is not possible, due to the lack of specific and precise biomarkers that give us this type of information. There are some signs that could be associated with these diseases, such as sleep disorders or gastrointestinal problems that suggest the possibility of neurodegeneration, however it is necessary to validate it as a diagnostic test.

-Is there any disease that can be associated to the appearance of a pathological neurodegeneration?

"The development of cardiovascular diseases and diseases that are associated with inflammatory processes can predispose to the development of neurodegenerative diseases, since they activate cellular responses that can alter the normal functioning of the Brain”

" It should be remembered that the third conference of "The route of thought" will be held on May 7 (11:45 hrs-Centro GAM), when the matron of the Universidad de Chile, Sandra Aramburú, and Mr. Iancu Cordescu, Executive director of the Fundación Chile Positivo, impart the Speech "How much do we know about HIV?


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