PUBLICATIONS





Affiliated publications

Ahumada-Castro, U., Silva-Pavez, E., Lovy, A., Pardo, E., Molgo, J. and Cárdenas, C. (2019) MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Autophagy 2019 Feb;15(2):358-361

Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM.(2019). Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nature Communications 10(1):1729.

Beltran S, Nassif M, Vicencio E, Arcos J, Labrador L, Cortes BI, Cortez C, Bergmann CA, Espinoza S, Hernandez MF, Matamala JM, Bargsted L, Matus S, Rojas-Rivera D, Bertrand MJM, Medinas DB, Hetz C, Manque PA, Woehlbier U. (2019). Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis. Mol Neurodegeneration 14, 14.

Erick Riquelme, Yu Zhang, Liangliang Zhang, Montiel Maria, Zoltan Michelle, Wenli Dong, Pompeyo Quesada, Ismet Sahin, Vidhi Chandra, Anthony San Lucas, Paul Scheet, Hanwen Xu, Samir M Hanash, Lei Feng, Nadim Ajami, Joseph Petrosino, Christine B. Peterson, Michael P. Kim, Cynthia L. Sears, James Robert White, Laura D.Wood11, Anirban Maitra, Matthew Katz, Robert Jenq, Jennifer Wargo, Florencia McAllister. (2019) Tumor Microbiome Diversity and Composition Determine Pancreatic Cancer Outcomes. Cell, in press

Arrázola MS, Court FA. (2019). Compartmentalized necroptosis activation in excitotoxicityinduced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology. Neural Regen Res. 2019 Aug;14(8):1385-1386. doi: 10.4103/1673-5374.253520

Arrazola, M.; Saquel, C.; Catalán, R.; Barrientos, S.; Hernandez, D.; Catenaccio, A.; Court, FA. (2019)Axonal degeneration is mediated by necroptosis activation. J Neurosci. 2019 Mar 13. pii: 0881-18. doi: 10.1523/JNEUROSCI.0881-18.201

Oñate M, Catenaccio A, Salvadores N, Saquel C, Martinez A, Moreno-Gonzalez I, Gamez Nazaret, Soto P, Soto C, Hetz C, Court FA. (2019). The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. BioRxiv

Patel A, Hayward JD, Tailor V, Nyanhete R, Ahlfors H, Gabriel C, Jannini TB, Coskun P, Abbou-Rayyah Y, Henderson R, Nischal KK, Islam L, Bitner-Glindzicz M, Hurst J, Valdivia LE, Zanolli M, Moosajee M, Brookes J, Papadopoulos M, Khaw PT, Cullup T, Jenkins L, Dahlmann-Noor A, Sowden JC. (2019) The Oculome panel test: next-generation sequencing to diagnose a diverse range of genetic developmental eye disorders. Ophthalmology. 2019 Jun;126(6):888-907. doi: 10.1016/j.ophtha.2018.12.050. Epub 2019 Jan 14.

Turner KJ, Hoyle J, Valdivia LE, Cerveny KL, Hart W, Mangoli M, Geisler R, Rees M, Houart C, Poole RJ, Wilson SW, Gestri G. (2019).Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 2019 Jan 29;14(1):e0211073. doi: 10.1371/journal.pone.0211073. eCollection 2019.

Paula García-Huerta, Paulina Troncoso-Escudero, Di Wu, Daniel R. Henríquez, Lars Plate, Pedro Chana-Cuevas, Cristian Saquel, Peter Thielen, Kenneth A. Longo, Brad J. Geddes, Pablo Sardi, Carlos Spichiger, Hans G. Richter, Felipe A. Court, R. Luke Wiseman, Christian Gonzalez-Billault, Steven Bergink, Rene L. Vidal* and Claudio Hetz*. (2019) Insulin-like growth factor 2 (IGF2) protects against Huntington´s disease through the extracellular disposal of protein aggregates. Science Translational Medicine

SanMartín C.D., Henriquez M., Chacón C., Ponce D.P., Salech F., and Behrens M.I*.(2018)Vitamin D Increases Aβ1- 40 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients. Curr Alzheimer Res. 15(6):561-569. ISSN: 1875-5828 (Online), ISSN: 1567- 205

Hernández DE, Salvadores NA, Moya-Alvarado G, Catalán RJ, Bronfman FC, Court FA.(2018)Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis. J Cell Sci. 2018 Nov 19;131(22). pii: jcs214684. doi: 10.1242/jcs.214684.

Gonzalez D, Rebolledo DL, Correa LM, Court FA, Cerpa W, Lipson KE, van Zundert B, Brandan E. (2018).The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Hum Mol Genet. 2018 Aug 15;27(16):2913-2926. doi: 10.1093/hmg/ddy204.

Müller M, Ahumada-Castro U, Sanhueza M, Gonzalez-Billault C, Court FA, Cárdenas C. (2018)Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging. Front Neurosci. 2018 Jul 13;12:470. doi: 10.3389/fnins.2018.00470. eCollection 2018.

Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C. (2018). IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nat Cell Biol. 2018 Aug;20(8):942-953. doi: 10.1038/s41556-018-0141-0. Epub 2018 Jul 16

Catenaccio A, Court FA. (2018)Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis. Methods Mol Biol. 2018;1739:329-337. doi: 10.1007/978-1-4939-7649-2_21. PMID: 29546717

De Gregorio C, Díaz P, López-Leal R, Manque P, Court FA. (2018).Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs. Methods Mol Biol. 2018;1739:299-315. doi: 10.1007/978-1-4939-7649-2_19.

López-Leal R, Diaz P, Court FA. (2018).In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia. Methods Mol Biol. 2018;1739:255-267. doi: 10.1007/978-1-4939-7649-2_16

Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, Rush T, Vizzuso D, Court FA, Bachi A, Wrabetz L, Feltri ML.(2018).A dual role for Integrin α6β4 in modulating Hereditary Neuropathy with liability to Pressure Palsies. J Neurochem. 2018 Jan 8. doi: 10.1111/jnc.14295.

Fuentes R, Letelier J, Tajer B, Valdivia LE*, Mullins MC*.(2018). Fishing forward and reverse: advances in zebrafish genetics and phenomics. Mechanisms of Development. PUBLICADO. ISSN: 0925-4773

Krasnow AM, Ford MC, Valdivia LE, Wilson SW, Attwell D. (2018).Regulation of myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nat Neurosci. 2018 Jan;21(1):24-28. doi: 10.1038/s41593-017-0031-y. Epub 2017 Dec 11.

Troncoso-Escudero, P., Parra, A., Nassif, M. Vidal, R.*(2018).Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson’s Disease. Front. Neurol., Suiza, publicada, ISSN 1664-2295, IF: 3.50

Valenzuela, V., Nassif, M.*, Hetz, C.*(2018). Unraveling the role of motoneuron autophagy in ALS, Autophagy. Autophagy, EEUU, publicada, ISSN: 1554-8627 Online ISSN: 1554-8635, IF: 11.1.

Mora J, Del Campo M, Villar J, Paolini F, Curzio G, Venuti A, Jara L, Ferreira J, Murgas P, Lladser A, Manubens A and Becker M. (2018). Immunotherapeutic potential of mollusk hemocyanins in combination with human vaccine adjuvants in murine models of oral cancer. J Immunol Res. 2019 Jan 20;2019:7076942. doi: 10.1155/2019/7076942. eCollection 2019.

Medinas DB, Rozas P, Martínez Traub F, Woehlbier U, Brown RH, Bosco DA, Hetz C*. (2018).Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 7;115(32):8209-8214.

Yıldırım Y, Ouriachi T, Woehlbier U, Ouahioune W, Balkan M, Malik S*, Tolun A*. (2018).Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility. Eur J Hum Genet. 26(6):876-885

Yıldız Bölükbaşı E, Mumtaz S, Afzal M, Woehlbier U, Malik S*, Tolun A*. (2018). Homozygous mutation in CEP19, a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly. J Med Genet. 55(3):189-197

Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. (2017). BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response. EMBO J. 2017 Jun 1;36(11):1640. doi: 10.15252/embj.201797020.

Catenaccio A, Llavero Hurtado M, Diaz P, Lamont DJ, Wishart TM, Court FA. (2017) Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. Cell Death Dis. 2017 Nov 9;8(11):e3166. doi: 10.1038/cddis.2017.489.

Bargsted L, Medinas DB, Martínez Traub F, Rozas P, Muñoz N, Nassif M, Jerez C, Catenaccio A, Court FA, Hetz C, Matus. (2017). Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model. Sci Rep. 2017 Oct 27;7(1):14266. doi: 10.1038/s41598-017-14399-5.

Salvadores N, Sanhueza M, Manque P, Court FA. (2017). Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders. Front Neurosci 2017 Sep4;11:451.doi:103389/fnins 2017 00451 eCollection 2017

Martin C, Leyton L, Hott M, Arancibia Y, Spichiger C, McNiven MA, Court FA, Concha MI, Burgos PV, Otth C. (2017). Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase. Front Cell Infect Microbiol 2017 Aug 22;7:371 doi: 10 3389/fcimb 2017 00371. eCollection 2017

Balboa, E., Castro, J., Pinochet, M.J., Cancino, G.I., Matías, N., José Sáez, P., Martínez, A., Álvarez, A.R., Garcia-Ruiz, C., Fernandez-Checa, J.C., and Zanlungo, S.*(2017)MLN64 induces mitocondrial dysfunction associated with increased mitocondrial cholesterol content. Redox Biol. 2017 Aug;12:274-284. doi: 10.1016/j.redox.2017.02.024. Epub 2017 Mar 2.

Argsted, L., Medinas, D.B., Martínez Traub, F., Rozas, P., Muñoz, N., Nassif, M., Jerez, C., Catenaccio, A., Court, F.A., Hetz, C.*, Matus, S.*(2017) Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model. Sci. Rep., publicada, ISSN:2045-2322, IF: 4.259.

Nassif M*, Woehlbier U, Manque P*(2017).The enigmatic role of C9ORF72 in autophagy. Front. Neurosc. (Suiza), publicada, ISSN: 1662-4548, IF: 3.508.

Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C. (2016).Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology. Sci Rep. 2016 Jul 18;6:30069. doi: 10.1038/srep30069.

Oñate M, Court FA, Hetz C. (2016). Bursting the unfolded protein response accelerates axonal regeneration. Neural Regen Res. 2016 Jun;11(6):892-3. doi: 10.4103/1673-5374.184453.

Vicente Valenzuela, Maritza Oñate, Claudio Hetz, Felipe A. Court. (2016). Injury to the nervous system: A look into the ER. Brain Res. 2016 Apr 23. doi:10.1016/j.brainres.2016.04.053

Margarita Calvo, Natalie Richards, Annina B Schmid, Alejandro Barroso, Lan Zhu, Dinka Ivulic, Ning Zhu, Philipp Anwandter, Manzoor A Bhat, Felipe A Court, Stephen B McMahon, David LH Bennett. (2016)Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury. Elife. 2016 Apr 19;5:e12661. doi: 10.7554/eLife.12661.

Felipe Court, Rodrigo Lopez, Jaime Alvarez. (2016). Origin of Axonal Proteins: Is the Axon-Schwann Cell Unit a Functional Syncytium?. Cytoskeleton (Hoboken). 2016 Oct;73(10):629-639 DOI: 10.1002/cm.21319.

Court FA, Alvarez J. (2016).Schwann Cell and Axon: An Interlaced Unit-From Action Potential to Phenotype Expression. Adv Exp Med Biol. 2016;949:183-201. DOI: 10.1007/978-3-319-40764-7 9.