MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Ahumada-Castro, U., Silva-Pavez, E., Pardo, E., Lovy, A., and Cárdenas, C. Autophagy. (Accepted).
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway. Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, Ramírez-Rodríguez O, Pessoa-Mahana H, Pavani M, Ferreira J, Cárdenas C, Araya-Maturana R. Scientific Report. 8(1):13190, 2018
Mitochondrial Regulation by Calcium as Basis of Neurodegeneration Associated to Aging. Müller, M., Ahumada-Castro, U., Gonzalez-Billault, C., Court, F.A., and Cárdenas, C. Frontiers in Neuroscience. 12:470, 2018
Hepatic Glutaminase activity and glutamine flux contributes to glucagon-stimulated gluconeogenesis and systemic glucose homeostasis. Miller, R.A., Shi, Y., Lu,W., Pirman, D.A., Jatkar, A., Blatnik, M., Wu, H., Cárdenas, C., Wan, M., Foskett, J.K., Park, J.O., Zhang, Y., Holland, W.L., Rabinowitz, J.D., Birnbaum, M.J. Nature Medicine. 24(4):518-524, 2018.
Mouse Tc17 cells display memory T cell-like traits. Flores-Santibáñez, F., Cuadra, B., Fernández, D., Rosemblatt, M., Núñez, S., Cruz, P., Gálvez-Cancino, F., Cárdenas, C.,
Lladser, A., Rosemblatt, M., Bono, M.R., and Sauma, D. Frontiers Immunology. 9:209, 2018.
Editorial: Inter- Organelle Calcium Communication in Cancer. Cardenas, C., Pinton, P., and Bultynck, G. Frontiers in Oncology. 8:14, 2018.
Calcium and Mitochondrial Metabolism in Cancer, a Novel Potential Target? Bustos, G., Cruz, P., Lovy, A., and Cárdenas C. Frontiers in Oncology. 7:199, 2017.
The mitochondrial complex(I)ty of cancer. Urra, FA., Muñoz, F., Lovy, A., Cárdenas, C. Frontiers in Oncology. 7:118, 2017.
Diabetic concentrations of Metformin inhibit platelet-mediated ovarian cancer cell
progression. Erices, R., Cubillos, S., Aravena, R., Santoro, F., Marquez, M., Orellana, R., Ramírez, C., González, P., Fuenzalida, P., Bravo, ML., Oliva, B., Kato, S., Ibañez, C., Brañes, J., Bravo, E., Alonso, C., García, K., Arab, C., Torres, VA., Godoy, A., Pereira, J., Bustos, G., Cardenas, C., Cuello, MA., and Owen, GI. Oncotarget. 8 (13): 20865-20880, 2017.
The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells. Schmeda-Hirschmann, G., Gomez, CV., de Arias, AR., Burgos-Edwards, A., Alfonso J., Rolon, M., Brusquetti, F., Netto, F., Urra, FA., Cárdenas, C. J Ethnopharmacology.
199: 106–118, 2017.
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. Cataldo, L., Mizgier, ML., Bravo, R., Jaña F., Cardenas, C., Llanos, P., Olmos PR., Galgani JE., Santos JL. and Cortés VA. PLOS One. 12(1):e0170213, 2017.
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae). Schmeda-Hirschmann, G., Quispe, C., Arana, GV., Theoduloz, C., Urra, FA. and Cárdenas C. Toxicon. 121:119-129, 2016.
InsP3R, the Calcium Whisperer: Maintaining Mitochondrial Function in Cancer. Lovy, A. Foskett, J.K. and Cardenas C. Molecular Cellular Oncology. 3(4):e1185563. 2016
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria. Cardenas, C., Muller, M, McNeal, A., Lovy, A., Jaňa, F., Bustos, G., Smith, N., Molgo, J., Diehl, A., Ridky, TW., and Foskett J.K. Cell Rep. 14(10):2313-24. 2016
Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease. Herrera A., Muñoz, P., Paris, I., Díaz-Veliz, G., Mora, S., Inzunza, J., Hultenby, K., Cardenas, C., Jaña, F., Raisman-Vozari, R., Gysling, K., Abarca, J., Steinbusch, HW. and Segura-Aguilar, J. Cell Mol Life Sci. 73(18):3583-972016, 2016
LETM1-dependent mitochondrial Ca2+
flux modulates cellular bioenergetics and proliferation. Doonan, P.J., Chandramoorthy, H.C., Hoffman, N.E., Zhang X., Cárdenas, C., Shanmughapriya, S., Rajan, S., Vallem S., Mallilankaraman, K., Chen, X., Foskett, J.K., Cheung J.Y., Houser, S.R., and Madesh, M. FASEB J. 28(11):4936-49, 2014.
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival. Mallilankaraman, K1., Doonan,
P1., Cárdenas, C1., Chandramoorthy, Müller, M., Miller, R., H.C., Hoffman, N.E., Gandhirajan, R., Molgó, J., Birnbaum, M., Rothberg, B., Mak, D., Foskett, J.K. and Madesh, M. Cell 151:630-644, 2012. 1These authors contributed equally to this manuscript.
MCUR1 is an essential component of mitochondrial Ca2+
uptake that regulates cellular metabolism. Mallilankaraman, K., Cárdenas, C., Doonan, P., Irrinki, K.M., Chandramoorthy, H.C., Madireddi, P., Yang, Y., Miller, R., Molgó, J., Kaufman, B., Foskett, J.K. and Madesh, M. Nature Cell Biol. 12:1336-1343, 2012.
Mitochondrial Ca2+ signals in autophagy. Cárdenas, C., and Foskett, J.K Cell Calcium 52: 44-51, 2012.
Constitutive activation of CREB by Alzheimer’s disease presenilin-driven InsP3R Ca2+ signaling. Müller, M., Cárdenas, C., Cheung, K.H. Mei, L., and Foskett, J.K. Proc Natl Acad Sci U S A. 108:13293-13298, 2011.
Structural evidence for perinuclear calcium microdomains in cardiac myocytes. Escobar, M., Cárdenas, C., Colavita, K., Petrenko, N.B. and Franzini-Armstrong. C. J. Mol Cell Car. 50:451-459, 2011.
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+
transfer to mitochondria. Cárdenas, C., Miller,
R.A., Smith, I., Bui, T., Molgo, J., Müller, M., Vais, H., Cheung, K.H., Yang, J., Parker, I., Thompson,
C., Birnbaum, M., Hallows, K.R. and Foskett J.K. Cell 142:270-283, 2010.
Visualization of inositol 1,4,5-trisphospate receptors on the nuclear envelope outer membrane by deep etching electron microscopy. Cárdenas, C., Escobar, M., Foskett, J.K., and Franzini-Armstrong, C. J. Structural Biology 171:372-381, 2010.
Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy derived cells. Cárdenas, C., Juretić, N., Bevilacqua, J.A., García, I., Figueroa, R., Hartley, R., Taratuto, A.L., Gejman, R., Riveros, N., Molgó J. and Jaimovich E. FASEB J. 24:3210-3221, 2010.
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Cheung, K.H., Shineman, D., Müller, M., Cárdenas, C., Mei, L., Yang, J., Tomita, T., Iwatsubo, T., Lee, V.M. and Foskett, J.K. Neuron 58:871-883, 2008.
Increase in IP3 mass levels and intracellular Ca2+ induced by Brevetoxin (Pbtx-3) depends on the membrane potential change in rat skeletal myotubes. Liberona, J.L., Cárdenas, C., Reyes, R., Molgó J. And Jaimovich E. Cell Calcium 44:289-297, 2008.
Single-channel recording of inositol trisphosphate receptor in the isolated nucleus of a muscle cell line. Kusnier C., Cardenas, C., Hidalgo, J., and Jaimovich E. Biol. Res. 39:541-553, 2006.
Nuclear inositol 1,4,5 triphosphate receptor isoforms regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation. Cárdenas, C., Liberona J.L., Molgó, J., Colasante, C., Mignery G.A. and Jaimovich, E. J.Cell Sci. 118: 3131-3140, 2005
Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells. Jaimovich, E., Mattei, C., Liberona, J.L., Cárdenas, C., Estrada, M., Barbier, J., Debitus, C., Laurent, D. And Molgó J. FEBS Letts. 579: 2051-2057, 2005.
Depolarization induces CREB phosphorylation via calcium and PKCα dependent pathways in skeletal muscle cells. Cárdenas C., Müller M., Jaimovich E., Pérez F., Buchuk D.,Quest A.F.G and Carrasco M.A. J. Biol. Chem. 279:39122-39131, 2004.
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. Ibarra, C., Estrada, M., Carrasco, L., Chiong, M., Liberona, J.L., Cardenas, C., Diaz-Araya, G., Jaimovich, E., and Lavandero, S. J. Biol. Chem. 279:7554-7565, 2004.
Dihydropiridine receptors as voltage sensors for a depolarization-evoked, IP3R-mediated, slow calcium signal in skeletal muscle muscle cells. Araya, R., Liberona, J.L., Cárdenas, C., Riveros, N., Estrada, M., Powell, J., Carrasco M.A., and Jaimovich, E. J.Gen.Physiol. 121: 3-16, 2003.
Calcium transients in 1B5 myotubes lacking ryanodine receptors are related to IP3 receptors. Estrada, M., Cárdenas, C., Liberona, J.L., Carrasco, M.A., Mignery, G. Allen, P.D. and Jaimovich, E. J.Biol.Chem. 276: 22868-22874, 2001.
