Felipe New

Director of the CIB details the progress of his research on the reduction of neuropathies caused by chemotherapies


Dr. Felipe Court, together with academics Bruno Nervi and Margarita Calvo, recounts the results of therapy where they use metformin, a drug used in diabetic patients, as a compound to reduce side effects that occur in cancer patients, among numbness, tingling, and pain in the hands and feet are counted.

The research began 6 years ago, when Dr. Felipe Court, director of the U. Mayor Center for Integrative Biology, began to collaborate with Dr. Bruno Nervi, who works at the Cancer Center of the Catholic University. They were later joined by Dr. Margarita Calvo, an expert in neuropathic pain.

Thus, after a time, the team that included doctoral students, medicine stud...

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U. Mayor signs research agreements with three top 70 universities in international rankings


Our house of studies established framework agreements with the universities Princeton (USA), Heidelberg (Germany) and Queensland (Australia), which will allow the exchange of academics and students, apply for funds together and create collaboration networks.

Taking a further step in its internationalization plan, the Universidad Mayor completed the signing of three agreements with major world study houses, located in the top 70 of various academic rankings, such as the Times Higher Education.

It’s about, Princeton University (United States), Heidelberg University (Germany) and the University of Queensland (Australia), with whom structured framework agreements were establishe...

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Pasantia Investigacion1

About 100 undergraduate students have completed internships at the U. Mayor Research Centers


Since 2018 to date, young people from different careers have participated in these instances, which seek to involve them in scientific projects or give them their first work experiences. The initiative, which is organized by the Research Immersion Program, has already been developed at the Santiago and Temuco locations.

Since 2018, nearly 100 students from different careers have participated in the internships organized by the Research Immersion Program, whose purpose is to involve young people in the research that takes place at the Universidad Mayor.

The Research and Teaching Link Coordinator, Victoria Paredes, commented that "the focus has ...

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U. Mayor researcher study suggests ketogenic diet may help treat a group of muscle diseases known as dysferlinopathies.


The work of Julio César Cárdenas, from the Center for Integrative Biology (CIB), found a possible relationship between this regimen - low in sugars and high in fats - and dysferlinopathies, a group of muscular diseases that generate progressive muscle weakness and that have not yet They have no cure or medical treatment.

Since the researcher of the Integrative Biology Center (CIB) of the U. Mayor, Julio César Cárdenas, completed his Doctorate in Skeletal Muscle at the University of Chile, he was attracted to this organ and its ability to modify or generate reactions that impact to the whole organism.

This interest led him to work and collaborate with Dr. Jorge Bevilaqcua, who ...

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Felipe Court: "The lower the level of education, the greater the probability of having Alzheimer's"


He is a neurobiologist and is dedicated to studying the aging process in order to preventively detect and treat neurodegenerative diseases such as Alzheimer's, Parkinson's, and dementia. In addition to the results he monitors in his laboratory, he dedicates part of his free time to the violin and microscopic photography.

On a hillside in Huechuraba, overlooking the business city, is one of the Universidad Mayor's campus. There, installed in an office next to his laboratory, is Felipe Court (44) full professor and director of the Center for Integrative Biology (CIB) of this university. Before arriving here, his academic career has been as follows: he studied biology and art at the C...

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VIP Projects: the tool that fosters the link between undergraduate and research carried out in the U. Mayor.


After a year since its implementation, this program of the Faculty of Interdisciplinary Studies, which seeks that academics, researchers and students work together, has 14 projects underway.

A new type of subject that allows the link between undergraduate and research carried out at the Universidad Mayor, in a format that encourages work on highly challenging and motivating interdisciplinary projects. That is what the “Vertically Integrated Projects VIP” program is in charge of, in charge of the Faculty of Interdisciplinary Studies of our house of studies.

This initiative was presented in September 2018 by Edward Coyle, an academic from the prestigious Georgia Tech, an Ameri...

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CIB Coordinator participated in the organization of the first meeting of Microscopy Units of Chilean universities


Dr. Ramón Ramírez is one of the founders of the Advanced Imaging and Bioinformatic Initiative (AIBI), which seeks to create a network of professionals and equipment nationwide.

The coordinator of the Microscopy Unit of the Center for Integrative Biology of the Universidad Mayor, Dr. Ramón Ramírez, was one of the organizers of the first meeting of professionals and specialists in the area belonging to different Chilean universities.

The activity was held on January 23 and 24 and 30 centers participated, in addition to institutions such as the University of Chile, Catholic, Austral and Andrés Bello, in addition to sponsoring companies such as Microsxchile, Micromundo, PerkinEl...

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Fotos Pagina Web

CIB researcher presented at the international congress on aging held in Valdivia


Dr. Felipe Court and Dr. Macarena Arrázola, postdoctoral fellow of the Center, demonstrated that by inhibiting a cellular pathway called necroptosis, memory loss can be delayed.

The director of the Center for Integrative Biology (CIB), Dr. Felipe Court, participated in the congress on aging and rejuvenation "ReBrain International Conference", which was held between January 22 and 24 in Valdivia.

The researcher presented the results made in his laboratory by Dr. Macarena Arrázola, who demonstrated that by inhibiting a cellular pathway called necroptosis, memory loss can be delayed in laboratory animal models.

“We discovered that a mechanism of neuronal degeneration par...

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Fotos Pagina Web

Largest study of its kind in which 50 centers participated: Finding 102 genes associated with autism opens doors to better diagnosis and more therapies.


Although it is estimated that cases of autistic disorder (ASD) have doubled in the last 10 years, their origin and causes are still unknown.

But research published yesterday in the scientific journal Cell delivers a sharper picture of this condition.

In a work carried out among 50 centers around the world, a group of scientists discovered 102 genes associated with the disorder, which means that there are clues of which vehicles would lead to the disease.

The finding is not minor if two data are considered: until 2015, there were only nine genes identified and, on the other hand, almost 50% of the cases are due to genetics, but how many of the 20 thousand genes are sti...

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Researcher U. Mayor describes gene associated with autism and regulating the formation of the cerebral cortex


The research, led by Dr. Gonzalo Cancino of the CIB, was published in the prestigious Cell Reports Magazine.

They were approximately 4 years of work, since the idea was conceptualized until it was finally published in the Cell Reports Magazine, led by Dr. Gonzalo Cancino, principal investigator of the Center for Integrative Biology at the Universidad Mayor. The research was carried out by members of Dr. Cancino's laboratory; the postdoctoral researcher Dr. Francisca Cornejo and the doctoral student Begoña Aranda, in collaboration with researchers from the United Sta...

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Erick Riquelme, medical technologist: Scientist works to create the first Chilean cancer research network


The idea is to generate contacts between experts who study in isolation, to be able to share information, contribute to their projects and, in the future, generate a national center.

Erick Riquelme (43) returned to Chile six months ago after spending nine years working on cancer research at the MD Anderson Cancer Center, University of Texas, one of the world's most important centers in this area. Now, back in the country, he works as a researcher at the Center for Integrative Biology (CIB) of the U. Mayor.

In the United States, together with a team of experts, he developed a research on pancreatic cancer that was published in one of the most prominent journals (Cell) and was...

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150 Years of Nature and Chilean scientists who have managed to publish in the famous magazine.


Founded by the Macmillan brothers in London, today the magazine is a benchmark of science worldwide, a place where several Chilean researchers have been part of their legacy.

In 2003, astronomers Mario Hamuy, National Prize for Exact Sciences of Chile (2015), and José Maza, National Prize for Exact Sciences (1999), discovered a novel method to measure the distance between stars. The research, named "An asymptotic giant branch star in the parent system of a type of supernova," and published in the journal Nature, served as inspiration and basis for astronomer Brian Schmidt to obtain the Nobel Prize in Physics in 2011 to discover that the universe was expanding rapidly.


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U. Mayor CIB researcher traveled to the laboratory of Dr. Koichi Kawakami, one of the drivers of transgenesis in zebrafish


Dr. Leonardo Valdivia did a transgenic line scan in the laboratory of this academic, in the National Institute of Genetics of Japan, with the aim of identifying the genetic basis of the formation of the visual system in vertebrates.

The researcher at the Center for Integrative Biology (CIB) of the Universidad Mayor, Dr. Leonardo Valdivia, was awarded a fund to visit the laboratory of Dr. Koichi Kawakami at the National Institute of Genetics of Japan, located in Mishima.

The academic of our house of studies made a positive evaluation of his stay of 10 days in the Asian country, both professionally and personally.

“Dr. Koichi Kawakami was one of the first people w...

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Erick Pagina Web

European Cancer Research Association selects the work of our researcher Erick Riquelme as one of the 10 most important works


Pancreatic cancer is a highly deadly disease, with limited therapeutic options. However, a small group (9%) survives for more than 5 years. The reasons that determine this survival are unknown. In this work, the role of the intratumoral microbiome and its interaction with the immune system in determining this greater survival was determined. It was detected that tumors of patients who have a long survival have greater intratumoral microbial diversity and a greater density of intratumoral immune infiltrate (CD3, CD8 and Granzyme B + T cells). Suggesting that microbial diversity contributes to the anti-tumor immune response, favoring the recruitment and activation of T cells, increasing the...

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Tesis Ejemplar

Medical technologists reward thesis work done by students of the U. Mayor


The College highlighted projects in the areas of Ophthalmology and Bioanalysis. The latter had the collaboration of researchers from the Center for Integrative Biology (CIB). The achievement is the result of interdiscipline and represents another step in the involvement of the centers in the undergraduate.

For the first time, the College of Medical Technologists of Chile gave recognition to the thesis work of students in five mentions. Thus, the Universidad Mayor obtained awards in two of them, corresponding to the areas of Ophthalmology and Bioanalysis.

Esteban Leyton and Diego Matus, who were guided by researchers from the C...

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Congreso Praga

CIB academics presented their research at congress on mitochondria and cancer in Prague


Dr. Julio César Cárdenas and Alenka Lovy were the only representatives of Chile in the event held in mid-September.

The role of mitochondria in cancer was the central theme of the congress held in mid-September in Prague, Czech Republic, where researchers from the Center for Integrative Biology (CIB) of the Universidad Mayor, Julio César Cárdenas and Alenka Lovy participated.

The Doctors presented their work on the regulation of mitochondria through calcium and what is its impact on tumor growth.

My presentation was a particular group of tumors that shows a special sensitivity to this regulation. While in the vast...

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Felipe Pagina Web

Director of the CIB U. Mayor participates in research that created a method that successfully slows the progress of Parkinson's


A new strategy to stop Parkinson's disease at an early stage is the result of three years of collaborative research between Dr. Felipe Court, director of the Center for Integrative Biology (CIB) of the Universidad Mayor and Claudio Hetz, director of the Millennium Institute of Biomedical Neuroscience (BNI) of the Faculty of Medicine of the Universidad de Chile.

The technique consists in blocking the destruction of the axon with a drug, a segment of the neuron similar to an extension or branching that allows communication between different brain cells.

Parkinson's disease that causes loss of motor control, occurs when dopaminergic neurons stop functioning or die. These cells ...

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U. Mayor is awarded $ 240 million and becomes the only private institution among the winners of the Fondequip.


The project, presented by academics from the Center for Integrative Biology, was one of 28 selected from 168 applicants, and will allow the acquisition of state -of- the art microscope, which will also be the first of its kind present in a university in South America.

Great news. A few days ago it was announced that the Universidad Mayor was the only private institution to win the Fondequip Medium Scientific and Technological Equipment Contest, which each year the National Commission for Scientific and Technological Research, Conicyt.

Our house of studies was awarded $ 240 million, the highest amount distributed by the entity, which will all...

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Universidad Mayor will sponsor the World Congress on Aging that will host Chile.


The event will take place between November 18 and 21 in Puerto Varas, and is part of a series of continental meetings on geoscience, a discipline that seeks to intervene to slow down the process of natural deterioration of the human organism.

During November, Chile will host the World Congress “International Perspectives on Gerocieties 2019”, organized by the Center for Gerocience, Mental Health and Metabolism (GERO) and sponsored by the Universidad Mayor.

The activity is part of a series of meetings sponsored by the network of Nathan Shock Center centers of excellence, which have been held in the United States, Australia, Spain, Israel, Singapore and China on this ...

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Pasantias Cib

Researchers from Uruguay and Mexico carry out an internship at the Center for Integrative Biology to study cell aging.


Sofía Ibarburu, Andrés Cawen and Daniel Moreno were interested in the work done by the unit's director, Dr. Felipe Court.

Two Uruguayan researchers and a Mexican do an internship at the Center for Integrative Biology (CIB) of the Universidad Mayor, with the aim of studying cell aging.

Sofía Ibarburu, who works at the Pasteur Institute in Montevideo on neurodegenerative diseases, arrived in Santiago interested in the work of the center's director, Dr. Felipe Court. “He went to present a job to Uruguay and a project on exosomes caught my attention and I contacted him,” he said.

The young woman said that her idea “is to study the senescence of a population of cells that...

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New finding adds evidence on the role of the microbiota in health: The state of the bacterial flora influences cancer survival


A study led by a Chilean scientist showed that greater diversity in the body's bacteria drives an increase in life in cases of pancreatic cancer.

Pancreatic cancer is an aggressive disease. In most cases, it does not respond to available treatments and causes thousands of deaths each year.

But, on the other hand, science has advanced in discovering the relationship between bacterial flora - known as microbiota - and health. And precisely cancer is a condition that has been associated with the composition of these microbes.

Now, new research led by Chilean scientist Erick Riquelme, a researcher at the Center for Integrative Biology at the Mayor University, has shown th...

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Encuentro Investigadores

2020 Accreditation and increase of indicators: Review the keys of the Third Meeting of Researchers U. Mayor


The event brought together 70 academics on the Huechuraba campus, where, for example, the number of indexed publications and the challenges that will bring the process to certify our quality in the Research area were highlighted.

A call to join and actively participate in the 2020 Accreditation Process was made by the Rector of the Universidad Mayor, Rubén Covarrubias Giordano, who led the inauguration of the Third Meeting of Researchers 2019.

The activity, held this Friday, August 9 at the Huechuraba campus, served both to highlight the results achieved in 2018 in the Research area, and to discuss the challenges that the process that will certify our quality for the fourth...

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Test gene therapy in Huntington's disease


Claudio Hetz and René Vidal used a method that replaces drugs in mice.

In Claudio Hetz's imagination, gene therapy is the simile of a vehicle that transports the essential merchandise to survive. "It is avant-garde, well emerging. Instead of using a pill with a chemical compound, a gene is used as a therapeutic agent," explains the director of the Millennium Institute of Biomedical Neuroscience of the Faculty of Medicine of the University of Chile.

The doctor of Biomedical Sciences uses this technique in a specific place in the brain. In simple, it introduces a gene wrapped in a virus, which is responsible for infecting damaged neurons. "Think of a capsule dru...

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Felipe Court

Scientist U. Mayor organized symposium on glial cells in Portugal


Dr. Felipe Court was the only representative who had the opportunity to present at the XIV European Meeting of Glial Cells in Health and Disease, among hundreds of applicants.

The director of the Center for Integrative Biology (CIB) of the Universidad Mayor, Dr. Felipe Court, organizes a symposium on glial cells and its effect on neuronal circuits, within the framework of the XIV European Meeting of Glial Cells in Health and Disease. in the city of Porto, Portugal, which gathered more than a thousand people.

This congress is the largest in the world associated with the study of the nervous system of a perspective not focused on the neuron but on the glial cells, which...

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Policy Paper Demencias

U. Mayor Scientists integrate team that delivered a national proposal to prevent dementias


Doctors Felipe Court and Julio Cesar Cardenas, members of the Center for Integrativa Biology (CIB),participate in the development of a document published in ther former Congress, that deliver an interdisciplinary proposal to approach this problem and that has been prepared by 70 researchers from Chile and Foreign.

Currently, 200 million people have some kind of dementia in the country. However, this pathology is not only affect the patient, but also their families and caregivers. Thus, and due to the fact that the Chilean population is aging, various forecasts indicate this problem is becoming more complex over the years.

Faced with this challenge, a group of more than 70 n...

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Artist and Scientist transform photographs of neural networks into works of art


“Cultivo", the exhibition by Juana Gomez, is based on the work of Dr. Felipe Court, principal of the Center for Integrative Biology of the U. Mayor.

The concepts of Art and Science came together to give life to the work of the renowned national artist, Juana Gomez, whose work has been cataloged as a true anatomical study, since it links disciplines such as mathematics and biology with photography, drawing and the embroidery.

Thus, her creation, called "Cultivo", arises from his dialogues with Dr. Felipe Court, principal of the Center for Integrative Biology (CIB) of the U. Mayor, who has focused his work on investigating how the nervous system works and why neurons die.


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Center for Integrative Biology presented advances in its research on Alzheimer's and ELA


The activity, carried out in the Huechuraba campus, sought to disseminate results and obtain complementary information that provides new perspectives for the studies that are under development.

The research seminars are a platform and, at the same time, an opportunity for the scientific community of the U. Mayor to communicate the progress and results of their research. In this context, on May 23 and 24, the Center for Integrative Biology (CIB) brought together, on the Huechuraba campus, students, academics and the general public to approach two issues in the field of health.

Dr. Ute Woehlbier, associate professor at the Center for Integrative Biology and organizer of the ac...

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U. Mayor and Huawei agree joint collaboration on technology and research


In a significant event for our institution, the Rector Rubén Covarrubias Giordano and the Executive Director of Huawei Chile, Dou Yong, signed an agreement that becomes an exchange of ideas, technical services and artificial intelligence, transcendent topics for the university.

Cloud services, quantum computing and artificial intelligence are some of the areas in which the Universidad Mayor and Huawei Chile can work together as of this year, thanks to the memorandum of understanding that both organizations signed this Wednesday May 22 in dependencies of the rectory.

The meeting was headed by Rector Rubén Covarrubias Giordano and Huawei Chile Executive Director, Dou Yong, who...

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Researcher published article in prestigious journal Nature Communications together with academics from Belgium


Dr. Diego Rojas Rivera, from the Center for Integrative Biology U. Mayor, recently published an article describing the complexity of the mechanisms of regulation of cell death, it could impact on different anti-inflammatory therapies.

A pioneering research team in Chile, formed at the eaves of the Center for Integrative Biology (CIB) of the Universidad Mayor, is beginning to see its first results.

In this case, we refer to Dr. Diego Rojas Rivera, who recently participated with the Inflammation Research Center of the University of Ghent (Belgium), in the development of an article that was published in the scientific journal Nature Communications and describes mechanisms of regu...

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Michael J. Fox Foundation supports Chilean laboratory to develop therapy against Parkinson's.

The Michael J. Fox Foundation for Research of the Parkinson’s gave a competitive fund of more than one hundred million pesos to the Center for Integrative Biology of the Universidad Mayor, directed by Felipe Court, to research for a possible therapy against the neurodegenerative disease that It has no cure.

"They are a study where new mechanisms that contribute to Parkinson's disease are discovered," says Court, biologist and doctor of Neuroscience.
“We found in the laboratory, that blocking a mecanism of the neurons, when they die, they produce the disease, we could block the development or progression of the symptoms associated with the dis...

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Rene Vidal Ruta Pensamiento

Universidad Mayor Researcher detailed the main behaviors that would boost the onset of brain diseases

At the second conference of "The Route of Thought", PhD. René Vidal, researcher at the CIB (Center for Integrative Biology), called for a healthy diet and constant physical and intellectual activity. In addition, he explained that the use of probiotics could help prevent pathologies such as Alzheimer's or Parkinson's.

"The route of thought", which is the cycle of speeches with which the Direction Public Engagement is looking to bring scientific topics to the community, had its second conference this year. This time, the protagonist was PhD. René Vidal, researcher at the Center for Integrative Biology (CIB) Universidad Mayor, who e...

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Director of the CIB awarded project of the Michael J. Fox Foundation to study new therapeutic targets against Parkinson's

PhD. Felipe Court explained that his proposal is to block pharmacologically the process of neuronal degeneration to stop the progression of the disease.

PhD. Felipe Court, director of the Center for Integrative Biology (CIB) of the Universidad Mayor, was awarded an important project of The International Michael J. Fox Foundation to study new therapeutic targets for Parkinson's disease. These projects are open to researchers around the world and are highly competitive.

The scientist explained that in his laboratory has been investigating the cellular mechanisms involved in neuronal deterioration in Parkinson's disease, which affects the nervous system and results in loss of...

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What Do We know about diseases that affect the brain? Scientific research as a motor of change in society

PhD. Rene Vidal, Researcher of the Center of Integrative Biology of the Universidad Mayor. PhD in science-biology and cellular.

The brain functions as a complex network, organized temporally and spatially. This organ, as it ages, is losing its ability to adapt to the paths it experiences daily. In Addition, it decreases its size and thus the neural communications (synapses), which are key to the normal functioning of this. On the second date of the cycle of the Route of thought, the academician of the Center of Integrative Biology U. Major, PhD. Rene Vidal, detailed the scientific efforts to create new tools that reverse or delay this process, in order to avoid the emergence of d...

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Doctorado Neurobiologia

PHD in neurobiology began its version 2019 with talks by Outstanding Scientists

In the encounter participated and exposed the National Science Award 2006, PhD. Cecilia Hidalgo, who reflected on the incorporation of women into the world of science. The welcome to the seminar was given by PhD. Nicole Trefault, who recently assumed the Direction of Doctoral Programs, seconded by the Director of the Integrative Biology Program, PhD. Melissa Calegaro, who greeted the new students that incorporate to the Doctoral Program: Begoña Aranda, Camila Weiss, Felipe Grunenwald and Güilherme Gischkow Rucatti, the latter coming from Brazil.

In Addi...

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Center of Integrative Biology began seminar cycle with talks about cancer cell treatment

On this session of seminar, PhD. Matías Escobar, who is a researcher at the University of Pennsylvania explained the ability of certain cell signaling pathways to mediate the reactivation and proliferation of cancer cells.

In women, breast cancer is the first cause of death worldwide, according to information from the International Journal of Cancer and institutions dedicated to studying this disease. And for PhD. Matias Escobar-Aguirre, post-doctoral researcher in the Department of Cancer Biology at the University of Pennsylvania, this "mortality" is mainly linked to the metastatic recurrence that follows the initial treatment of cancer.


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Geroscience Center for Brain Health and Metabolism seeks motivated post-doctoral researchers


Information about GERO available at

Topics include:

– Cytoskeleton dysfunction in aging and neurodegenerative diseases
– Proteostasis in aging and neurodegenerative diseases
– Axonal degeneration and regeneration in neurodegenerative diseases
– Age-dependent microbiome changes
– Mitochondrial dysfunction in aging and neurodegenerative diseases
– Novel models for aging research (Killifish, Droshopila, mice)
– Stem cell generation (iPSC) from human neurodegenerative conditions
– Neuropsychology of aging and neurodegeneratives diseases
– Aging: Psychosocial studi...

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Biome Therapeutics is looking for Lead Scientist


Call for a researcher to work in Biome Therapeutics Company, Santiago, Chile.

Biome Therapeutics, a startup dedicated to develop innovative technology from the gut microbiome, calls interested parties to apply for a position as Lead Scientist for projects associated with the study of the human microbiome and its possible therapeutic effects.

Functions: The activities associated with this charge will be the development of high quality research in the area of analysis of gut microbiome, isolation of bacterial strains and studies of the effect of the microbiome in different cellular models "in vitro".

Requirements: professional degree or Bachelor's degree in...

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Center of Integrative Biology at Universidad Mayor seeks a Veterinary Technician


The Center of Integrative Biology at Universidad Mayor (CIB-UM) is offering a position as Veterinary Technician associated to the FONDAP program of the Geroscience Center.

The selected professional must demonstrate experience and potential to develop the activities associated with the position, being able to fulfill the following functions:

Do the change of boxes, water fountains, grilles, in conjunction with washing crates, troughs and grids.
Prepare spare boxes in advance to the days of changing boxes, preparing enrichment material for autoclaving and then providing it to the mice.
Keep clean and in-order the dependencies of the animal facilities.

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With cutting-edge technology: Chilean study seeks to create the rejuvenating brain injection to fight Parkinson's


A scientific team at the U. Mayor, led by Dr. René Vidal, works on a gene treatment to delay and reverse the symptoms of the disease.

By Gabriel Arce
Monday 28, January 2019

According to recent data from the Ministry of Health, more than 40 thousand Chileans live with Parkinson's. Therefore, the alert is a fact, since the World Health Organization (WHO) estimates that the number of pe...

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U. Mayor granted with 8 Fondecyt Projects for a total sum of CLP$1600m


The scientific initiatives are aimed at the study of neurodegenerative diseases, aging, the development of ecosystems and genomics, among other areas.

A new and important achievement in research is the one that the Universidad Mayor has just obtained, after the awarding of 8 regular Fondecyt projects, which were presented by its Genomics, Ecology and Environment Centers (GEMA); Modeling and Monitoring of Ecosystems; Integrative Biology; Society and Health; and Optics and Quantum Information.

These initiatives represent 40% of the total of the works presented by this house of studies (20), higher than the national average, which reached an average of 20%.

It should be ...

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The effect of autophagy on brain health


All Content under the Creative Commons Attribution-NonCommercial 4.0 International License of HEUREKA.

By Melissa Calegaro, PhD in Biomedical Sciences. Assistant Professor and Director of the Doctorate Program in Neurobiology Universidad Mayor.

I am an initial training pharmacist. However, since I started this career, the question I wanted to help answer was why our brain gets sick. In the second semester I asked to work as a volunteer in a laboratory during my free time. I wanted to learn about this organ and how to treat it in case of illness. From there I never left science, nor the ques...

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Can Aging be controlled? Check how our Center for Integrative Biology Works


Check the interview with Dr. Felipe Court, who talks about Geroscience, an area which look for solve the mysteries of aging, pointing at common diseases.

Click for the first part of the interview

In a new edition of ""Exploradores: Del Átomo al Cosmos", from 24 Horas Channel, the main topic is how science is working with the growing of life expectancy.

Click fot the second part of the interview

Source: Diario Mayor.<...

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Center for Integrative Biology is awarded 2 projects "Fondecyt de Iniciación 2018", from the 13 awarded to Universidad Mayor.


The two projects are the following:

The aim of this project is to study the cellular and regulatory impact over fish visual system formation upon Vsx transcription factors removal. 

The general aim of this project is to determine the role of two autophagy-regulatory proteins, Rubicon and Pacer, on cell death induced by TNF and to define their potential of therapeutic targets en Mesenchymal Stem Cells.


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Model Network Brainbow Resize Copia

Scientists from the Center for Integrative Biology at Universidad Mayor obtains two Conicyt projects for the formation of International Networks 2018.


The grant entitled “Modelling human brain disorders using iPSCs and brain organoids” aims to create a network among the researchers Dr. Gonzalo Cancino, Dr. Melissa Calegaro and Dr. Leonardo Valdivia at the Center for Integrative Biology at Universidad Mayor in Chile and the UK based researchers Dr. Madeline Lancaster at University of Cambridge and Dr. Greg Findlay at University of Dundee. This network is focused in understanding how the human brain develops and how genes associated to neurodevelopmental disorders regulate human brain cortical development using human iPSCs, brain organoids and phospho-proteomic analysis.

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Dr. Mario Sanhueza from the Center for Integrative Biology at Universidad Mayor obtains a project for insertion in the Academia.


Conicyt´s grant Installation in the academy seeks to contribute to the institutional strengthening of national higher education entities, by hiring researchers who start their independent career, in order to close the gap between the last stages of doctoral training and their insertion in the academy

The installation proposal of Dr. Mario Sanhueza meets the guidelines of the development plan of the Center for Integrative Biology of the University, based on high quality science, a high level of scientific collaboration, and experience in teaching and outreach.

In his research project Dr. Sanhueza will try to understand mechanisms with the potential to delay the onse...

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CIB Investigator conducting a research internship at Institut Curie, Paris, France


Through an ECOS-Conicyt project association between Dr. Felipe Court Lab (CIB) and Christophe Lamaze Lab (Institute Curie), the investigator Cristian Saquel is conducting a research internship in Paris. He is studying the association between mechanic deformation of cells in NS and the liberation of molecular messages through extra cellular vesicles, a mechanism which could be related to tumours growth in NS.



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Felipe court, Ph.D. took part in the international congress organized by Spinal Research Foundation in UK.


Felipe Court, Ph.D. took part in the International Congress organized by the Spinal Research Foundation in UK, one of the biggest foundations in that country that support researching related to SN regeneration, specially in spinal cord damage conditions. This international congress is made every year and the speakers are invited to show their findings. Dr. Court spoke about his investigation associated to SN regeneration and new information related to genetic networks which could participate in regeneration after spinal cord damage. This new findings could eventually be therapeutic targets to improve regeneration and functional regeneration after the damage to SN.


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Vice Chancellor explained the unknown role of bacteria in Alzheimer or food alergies.


Patricio Manque, Ph.D in Microbiology & Inmunology from U. Federal do Sao Paulo (Brasil), offered a lecture in which highlighted the study in microbes as a "revolutionary tool" for medecine.

¿What does have in common Alzheimer and Periodontitis? ¿Cesarean and food alergies in kids? ¿Depresion and diet?. For Dr. Manque, Researching Vice Chancellor from U. Mayor, there's a created relationship. He stated so in the lecture "The super organism: How our microbes impact our health", offered this tuesday at GAM.

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Through lectures about the challenges of future, U.Mayor took part in "Protagonistas 2030"


Also there was proposed a group of ideas to help to be prepared to a society more aged, like the investigation of this topic in an interdisciplinary way, joining public policies and personalized medicine; boost the early literacy for a healthy retirement, break the standard of the life course for a better functioning of elder stage; encourage the social and biological protection to break the chains that cause stress.

In this activity, organized by El Mercurio journal, Patricio Manque, Ph.D and Esteban Calvo, PhD. talked about the revolution of human genome and the aging phenomenon in our country.

Dr. Manque offered a lecture about the human revolution of g...

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Second Contest: Centers for Research on Aging Stay


Presentation: This contest is focused on Postdoctoral Investigators (Ph.D Students will be exeptional considered), associated to GERO whom want to carry an intership to develop collaboration projects between GERO and Research Institutions on Aging, like Buck and ERIBA. The center will provide the necesary funding up to 4 postdoctoral stays.

Benefits: Each stay will be granted with:

a) An Economy Class Ticket Santiago-Destination-Santiago up to $1.500.000CLP
b) An economic help up to $1.500.000 for PostDoc or $1.000.000 for Ph.D students
c) Travel Insurance during the staying.


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Research Centers from U.Mayor open their doors to undergraduates to show how they work


Difussion Day is organized by Biotechnology School, its objective is to bring the science closer to students and to show the laboratories and current projects. 

The activity was set in two parts, a presentation by each Investigator at the main auditorium in Campus Huechuraba, and then a guided visit to the laboratories.


Felipe Court, Ph.D, Director from CIB stated: "our presentation contributed to invite Biotechology students in a way they could know what are the research lines from our 11 Investigators, who study different as...

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Gic Noticia

Investigator warns :"Stem cells are not magic"


Molecular Biology Ph.D is worried about the lack of integrity of some treatments.

Gonzalo Cancino, Investigator from the Center for Integrative Biology of Universidad Mayor, states that stem cells "are not a panacea" and says that some health centers don't comply with what they offer.  "In a certain moment, it looked like stem cells could cure a lot of diseases, but that didn't happen. Parents who used to keep their children's umbilical cord, nowadays don't trust in health centers who offer to conserve the cells in exchange for money because of several cases in which they were misused. They even weren't stocked in NO2 at -180°C, the correct tempera...

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Chileans are searching for the origin of autism in a brain protein


Scientifics analize the role of PTPRD gen at embrionary level to know how affects to bran functioning.

We still don't know so much on Autist Spectrum disorder ASD, a group of complex disorders of brain development, which cause is linked to genetic and enviromental factors. To understand its origin, a group of Chilean investigators from the Center for Integrative Biology CIB, from the Universidad Mayor, lead by Gonzalo Ignacio Cancino, Cell and Molecula Biology PhD, are carrying out studies on PTPRD protein, present in the brain of autism patients.

Source: Diario La hora, María Eugenia Durán 03/27/201...

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Interview to Felipe Court in Duna Radio


Felipe Court, Director of the Center for Integrative Biology, talks about the investigation to face neurodegenerative diseases. Several experiments in flies could allow the extension of their lives through a procedure which could be replicated in human beings. 

You can check the full interview in the following link  click here

Source: Duna Radio, Aire fresco, June 4th 2018


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