Rene Vidal

Castillo V, Onate M, Woehlbier U, Rozas P, Andreu C, Medinas D, Valdes P, Osorio F, Mercado G, Vidal RL, Kerr B, Court FA, Hetz C. Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration. PLoS One. 2015;10(9):e0136620.

Mercado G, Castillo V, Vidal R, Hetz C. ER proteostasis disturbances in Parkinson's disease: novel insights. Front Aging Neurosci. 2015;7:39.

Rivas A, Vidal RL, Hetz C. Targeting the unfolded protein response for disease intervention. Expert Opin Ther Targets. 2015;19(9):1203-18.

Garcia-Huerta P, Bargsted L, Rivas A, Matus S, Vidal RL. ER chaperones in neurodegenerative disease: Folding and beyond. Brain Res. 2016;1648(Pt B):580-7.

Garcia-Huerta P, Troncoso-Escudero P, Jerez C, Hetz C, Vidal RL. The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases? Brain Res. 2016;1649(Pt B):173-80.

Martinez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdes P, Thielen P, Schneider BL, Kerr B, Valdes JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. Regulation of Memory Formation by the Transcription Factor XBP1. Cell Rep. 2016;14(6):1382-94.

Woehlbier U, Colombo A, Saaranen MJ, Perez V, Ojeda J, Bustos FJ, Andreu CI, Torres M, Valenzuela V, Medinas DB, Rozas P, Vidal RL, Lopez-Gonzalez R, Salameh J, Fernandez-Collemann S, Munoz N, Matus S, Armisen R, Sagredo A, Palma K, Irrazabal T, Almeida S, Gonzalez-Perez P, Campero M, Gao FB, Henny P, van Zundert B, Ruddock LW, Concha ML, Henriquez JP, Brown RH, Hetz C. ALS-linked protein disulfide isomerase variants cause motor dysfunction. EMBO J. 2016;35(8):845-65.

Troncoso-Escudero P, Parra A, Nassif M, Vidal RL*. Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease. Front Neurol. 2018;9:860.

Urra H, Henriquez DR, Canovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic A, Gonzalez-Billault C, Hetz C. IRE1alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nat Cell Biol. 2018;20(8):942-53.

Garcia-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henriquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, Naphade S, Sardi SP, Spichiger C, Richter HG, Court FA, Tshilenge KT, Ellerby LM, Wiseman RL, Gonzalez-Billault C, Bergink S, Vidal RL*, Hetz C. Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates. Acta Neuropathol. 2020;140(5):737-64.

Troncoso-Escudero P, Sepulveda D, Perez-Arancibia R, Parra AV, Arcos J, Grunenwald F, Vidal RL.* On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease. Front Aging Neurosci. 2020;12:571185.

Perez-Arancibia R, Ordonez JL, Rivas A, Pihan P, Sagredo A, Ahumada U, Barriga A, Seguel I, Cardenas C, Vidal RL, Hetz C, Delporte C. A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington's disease. PLoS One. 2021;16(7):e0254834.

Troncoso-Escudero P, Hetz C, Vidal RL*. Therapeutic potential of insulin-like growth factor 2 in Huntington's disease: controlling proteostasis to alleviate the load of misfolded protein. Neural Regen Res. 2021;16(8):1564-5.

Troncoso-Escudero P, Vidal RL*. Insulin-like Growth Factor 2: Beyond its Role in Hippocampal-dependent Memory. Journal of Cellular Immunology. Journal of Cellular Immunology 2021;3(1): 46-52.

Vidal RL, Sepulveda D, Troncoso-Escudero P, Garcia-Huerta P, Gonzalez C, Plate L, Jerez C, Canovas J, Rivera CA, Castillo V, Cisternas M, Leal S, Martinez A, Grandjean J, Sonia D, Lashuel HA, Martin AJM, Latapiat V, Matus S, Sardi SP, Wiseman RL, Hetz C. Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration. Mol Ther. 2021;29(5):1862-82.

Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cardenas JC, Plate L, Palacios AG, Hetz C. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. EMBO J. 2022;41(22):e111952.

Espinoza S, Grunenwald F, Gomez W, Garcia F, Abarzua-Catalan L, Oyarce-Pezoa S, Hernandez MF, Cortes BI, Uhrig M, Ponce DP, Duran-Aniotz C, Hetz C, SanMartin CD, Cornejo VH, Ezquer F, Parra V, Behrens MI, Manque PA, Rojas-Rivera D, Vidal RL, Woehlbier U, Nassif M. Neuronal Rubicon Represses Extracellular APP/Amyloid beta Deposition in Alzheimer's Disease. Cells. 2022;11(12).

Marin T, Valls C, Jerez C, Huerta T, Elgueta D, Vidal RL, Alvarez AR, Cancino GI. The c-Abl/p73 pathway induces neurodegeneration in a Parkinson's disease model. IBRO Neurosci Rep. 2022;13:378-87.

Perez-Arancibia R, Cisternas-Olmedo M, Sepulveda D, Troncoso-Escudero P, Vidal RL.* Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics. Front Neurosci. 2022;16:1084493.

Sepulveda D, Cisternas-Olmedo M, Arcos J, Nassif M, Vidal RL*. Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson's Disease. Front Mol Neurosci. 2022; 15:805087.

Sepulveda D, Grunenwald F, Vidal A, Troncoso-Escudero P, Cisternas-Olmedo M, Villagra R, Vergara P, Aguilera C, Nassif M, Vidal RL*. Insulin-like growth factor 2 and autophagy gene expression alteration arise as potential biomarkers in Parkinson's disease. Sci Rep. 2022;12(1):2038.

Arancibia-Opazo S, Contreras-Riquelme JS, Sanchez M, Cisternas-Olmedo M, Vidal RL, Martin AJM, Saez MA. Transcriptional and Histone Acetylation Changes Associated with CRE Elements Expose Key Factors Governing the Regulatory Circuit in the Early Stage of Huntington's Disease Models. Int J Mol Sci. 2023;24(13).

Muller-Nedebock AC, Dekker MCJ, Farrer MJ, Hattori N, Lim SY, Mellick GD, Rektorova I, Salama M, Schuh AFS, Stoessl AJ, Sue CM, Tan AH, Vidal RL, Klein C, Bardien S. Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease. NPJ Parkinson’s Dis. 2023;9(1):110

Vega-Galvez A, Gomez-Perez LS, Zepeda F, Vidal RL, Grunenwald F, Mejias N, Pasten A, Araya M, Ah-Hen KS. Assessment of Bio-Compounds Content, Antioxidant Activity, and Neuroprotective Effect of Red Cabbage (Brassica oleracea var. Capitata rubra) Processed by Convective Drying at Different Temperatures. Antioxidants (Basel). 2023;12(9).

Vega-Galvez A, Uribe E, Pasten A, Camus J, Gomez-Perez LS, Mejias N, Vidal RL, Grunenwald F, Aguilera LE, Valenzuela-Barra G. Comprehensive Evaluation of the Bioactive Composition and Neuroprotective and Antimicrobial Properties of Vacuum-Dried Broccoli (Brassica oleracea var. italica) Powder and Its Antioxidants. Molecules. 2023;28(2).

Villablanca C, Vidal R, Gonzalez-Billault C. Are cytoskeleton changes observed in astrocytes functionally linked to aging? Brain Res Bull. 2023; 196:59-67.

Arcos J, Grunenwald F, Sepulveda D, Jerez C, Urbina V, Huerta T, Troncoso-Escudero P, Tirado D, Perez A, Diaz-Espinoza R, Nova E, Kubitscheck U, Rodriguez-Gatica JE, Hetz C, Toledo J, Ahumada P, Rojas-Rivera D, Martin-Montanez E, Garcia-Fernandez M, Vidal RL*. IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models. Cell Death Discov. 2023;9(1):438.

Active

2016-2020 FONDAP 15150012

2023-2026 Fondecyt regular 1230980

Completed

2015-2018 Fondecyt regular 1150608

2017-2019 FONDEF D11E1007

2016-2020 Iniciativa Científica Milenio P09015F

2019-2022 Fondecyt regular 1191003

René Vidal, Investigador principal, Universidad Mayor

Carolina Jerez, Asistente de investigación y lab manager, Universidad Mayor

Marisol Cisternas, Estudiante de doctorado en Neurobiología, Universidad Mayor

Bárbara Saavedra, Estudiante de doctorado en Neurobiología, Universidad Mayor

Tomás Huerta, Estudiante de doctorado en Neurobiología, Universidad Mayor

Valentina Urbina, Estudiante de doctorado en Neurobiología, Universidad Mayor

Cristopher Villablanca, post doctorante, beca Fondecyt-ANID, Universidad Mayor.

Luis Gómez, post doctorante, beca Fondecyt-ANID, Universidad Mayor.

Valentina Urra, estudiante de pregrado Biotecnología, Universidad Mayor

Javiera Cárdenas, estudiante de pregrado Tecnología Médica, Universidad Mayor

Nicolás Palavicino, estudiante de pregrado Tecnología Médica, Universidad Mayor

Former Lab Members

Paulina Troncoso, estudiante de Doctorado en Ciencias Biomédicas, ahora Investigadora en el Laboratorio de Diagnóstico molecular y Biomarcadores de Clínica Alemana, Santiago

Denisse Sepúlveda, post doctorante, ahora directora área de ensayos clínicos Cellus, Chile

Alejandra Parra, estudiante de Doctorado en Ciencias Biomédicas, ahora Investigadora en Universidad occidental de Ontario, Canadá

Rodrigo Perez, estudiante de Doctorado en Ciencias Biomédicas, profesor Universidad San Sebastián

Felipe Grünenwuald, estudiante de doctorado en Neurobiología, ahora post doctorante en Centro de Investigación e innovación Biomédica en Universidad de los Andes

Sandra Espinoza, asistente de investigación y lab manager, ahora Investigadora en fundación Ciencia y Vida

María José Hormazabal, estudiante de doctorado en Ciencias Biomédicas, ahora directora escuela de Nutrición Universidad Mayor

Javiera Arcos, estudiante de doctorado en Neurobiología, ahora asistente de investigación en laboratorio de control de proteostasis y biomedicina de la Universidad de Chile

National

Rodrigo Pacheco, Fundación Ciencia y Vida, Chile.

Melissa Nassif, Center for Biomedicine, Universidad Mayor, Chile.

Diego Rojas, Center for Biomedicine, Universidad Mayor, Chile.

Ute Woehlbier, Center for Integrative Biology, Universidad Mayor, Chile.

Felipe Court, Center for Integrative Biology, Universidad Mayor, Chile.

Rodrigo Díaz, Universidad Santiago de Chile, Chile.

Pedro Chana, Centro de Trastornos del movimiento, Chile

Carlos Aguilera; Hospital Fach, Chile

International

María García Fernández, Universidad de Málaga, España.

Ulrich Kubitscheck, Universidad de Bonn, Alemania.