Patricio Manque

Full Professor

He obtained his PhD in Microbiology and Immunology at the Federal University of Sao Paulo, Brazil (UNIFESP). Later he completed a Postdoctorate at the institution and a second Postdoc in Genomics at Virginia Commonwealth University, United States. Later, he returned to Chile where he founded, the first Genomics Center in Chile at Universidad Mayor. At this center, he began applying systems biology approaches to study neurodegenerative diseases. At the Center for Integrative Biology (CIB) he uses network theory to identify new therapeutic targets in neurodegenerative diseases and cancer.

Patricio Manque



  • Cordova-Delgado M, Pinto MP, Pizarro G, Koch E, Vargas C, Hernández M, Nourdin G, Saldivia P, Rodriguez Z MP, Berkovits A, Manque P, Rios JA, Garcia-Bloj B, Garrido M. Proteogenomic analysis in an early onset diffuse gastric cancer patient revealed alterations in PIK3R1, TP53, SMAD4 and a potential role of the PI3K-AKT and EGFR pathways: a case report. J Gastrointest Oncol. 2022 Aug;13(4):2057-2064. doi: 10.21037/jgo-21-780
  • Espinoza S, Grunenwald F, Gomez W, García F, Abarzúa-Catalan L, Oyarce-Pezoa S, Hernandez MF, Cortés BI, Uhrig M, Ponce DP, Durán-Aniotz C, Hetz C, SanMartín CD, Cornejo VH, Ezquer F, Parra V, Behrens MI, Manque PA, Rojas-Rivera D, Vidal RL, Woehlbier U, Nassif M.Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer's Disease. Cells. 2022 Jun 7;11(12):1860. doi: 10.3390/cells11121860.
  • Bergmann CA, Beltran S, Vega-Letter AM, Murgas P, Hernandez MF, Gomez L, Labrador L, Cortés BI, Poblete C, Quijada C, Carrion F, Woehlbier U, Manque PA. The Autophagy Protein Pacer Positively Regulates the Therapeutic Potential of Mesenchymal Stem Cells in a Mouse Model of DSS-Induced Colitis. Cells. 2022 Apr 30;11(9):1503. doi: 10.3390/cells11091503
  • Cordova-Delgado M, Pinto MP, Regonesi C, Cereceda L, Reyes JM, Itriago L, Majlis A, Rodríguez P, Fassler A, Mahave M, León ME, Gallardo J, Rodríguez Z MP, Berkovits A, Manque P, Ríos JA, Garcia-Bloj B, Garrido M.Mutational Landscape and Actionable Target Rates on Advanced Stage Refractory Cancer Patients: A Multicenter Chilean Experience. J Pers Med. 2022 Jan 31;12(2):195. doi: 10.3390/jpm12020195
  • Leyton E, Matus D, Espinoza S, Benitez JM, Cortés BI, Gomez W, Arévalo NB, Murgas P, Manque P, Woehlbier U, Duran-Aniotz C, Hetz C, Behrens MI, SanMartín CD, Nassif M. DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease. J Alzheimers Dis. 2021;82(s1):S163-S178. doi: 10.3233/JAD-201264
  • Ostria-Gallardo E, Larama G, Berríos G, Fallard A, Gutiérrez-Moraga A, Ensminger I, Manque P, Bascuñán-Godoy L, Bravo LA.Decoding Gene Networks Modules That Explain the Recovery of Hymenoglossum cruentum Cav. After Extreme Desiccation. Front Plant Sci. 2020 May 15;11:574. doi: 10.3389/fpls.2020.00574
  • Vicencio E, Beltrán S, Labrador L, Manque P, Nassif M, Woehlbier U. Implications of Selective Autophagy Dysfunction for ALS Pathology. Cells. 2020 Feb 7;9(2):381. doi: 10.3390/cells9020381
  • Beltran S, Nassif M, Vicencio E, Arcos J, Labrador L, Cortes BI, Cortez C, Bergmann CA, Espinoza S, Hernandez MF, Matamala JM, Bargsted L, Matus S, Rojas-Rivera D, Bertrand MJM, Medinas DB, Hetz C, Manque PA, Woehlbier U. Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis. Mol Neurodegener. 2019 Mar 27;14(1):14. doi: 10.1186/s13024-019-0313-9
  • De Gregorio C, Díaz P, López-Leal R, Manque P, Court FA. Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs.
    Methods Mol Biol. 2018;1739:299-315. doi: 10.1007/978-1-4939-7649-2_19
  • Matamala, J.M., R. Arias-Carrasco, C. Sanchez, M. Uhrig, L. Bargsted, S. Matus, V. Maracaja-Coutinho, S. Abarzua, B. van Zundert, R. Verdugo, P. Manque, and C. Hetz. 2018. Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis. Neurobiol. Aging. 64:123–138. doi:10.1016/j.neurobiolaging.2017.12.020.
  • Salvadores N, Sanhueza M, Manque P, Court FA.Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders. Front Neurosci. 2017 Sep 4;11:451. doi: 10.3389/fnins.2017.00451
  • Nassif M, Woehlbier U, Manque PA. The Enigmatic Role of C9ORF72 in Autophagy. Front Neurosci. 2017 Aug 3;11:442. doi: 10.3389/fnins.2017.00442
  • Sánchez, C., J. Villacreses, N. Blanc, L. Espinoza, C. Martinez, G. Pastor, P. Manque, S.F. Undurraga, and V. Polanco. 2016. High quality RNA extraction from Maqui berry for its application in next-generation sequencing. Springerplus. 5. doi:10.1186/s40064-016-2906-x
  • Isaza JP, Galván AL, Polanco V, Huang B, Matveyev AV, Serrano MG, Manque P, Buck GA, Alzate JF. Revisiting the reference genomes of human pathogenic Cryptosporidium species: reannotation of C. parvum Iowa and a new C. hominis reference. Sci Rep. 2015 Nov 9;5:16324. doi: 10.1038/srep16324
  • Villacreses J, Rojas-Herrera M, Sánchez C, Hewstone N, Undurraga SF, Alzate JF, Manque P, Maracaja-Coutinho V, Polanco V.Deep sequencing reveals the complete genome and evidence for transcriptional activity of the first virus-like sequences identified in Aristotelia chilensis (Maqui Berry). Viruses. 2015 Apr 3;7(4):1685-99. doi: 10.3390/v7041685


1. The lab of Network Biology

1. The lab of Network Biology

Headed jointly by Dr. Patricio Manque and myself combines systems biology with molecular biology, biochemistry, cellular and animal studies to understand mechanisms of human disease. We apply network-based approaches to build disease-specific networks allowing us to identify new genes, pathways, subnetworks responsible for the molecular pathology of a disease. To achieve this, we collect large data sets (RNAseq, CNV, HUGE, Proteomics) and combine them with a diverse set of bioinformatic tools, e.g. convergent analysis. This approach permits us, (i) to identify topological changes in the overall structure of the network, (ii) to unravel new genes or new interactions associated with a disease, and (iii) to detect potential master regulators in the disease specific networks. Once we bioinformatically identified a candidate gene we investigate its role during disease with a broad set of experimental tools. Our current focus is the characterization of novel genes inserted in the diseasosome of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In addition, by using OMICs approach our lab is focused in understanding the role of intestinal microbiome in neurodegenerative diseases.



2021-2025 FONDECYT Regular 1210507 (Co-Investigador)


2015-2019 FONDECYT Regular 1150743 (Co-Investigador)

2015-2019 FONDECYT Regular 1151393 (Co-Investigador)

2014-2017 USA/Chile grant USA-2013-0041 (Investigador responsable)

2012-2016 FONDECYT Regular 1131038 (Co-Investigador)

2012-2015 Anillo ACT1109 (Investigador responsable)


Fernanda Hernandez Berrios
Lab Manager

Bachelor in Biotechnology Engineering from Universidad Andres Bello, Chile. In charge of general lab management and organization, in addition to molecular biology of the laboratory.
Cristian Bergmann
Ph.D. student

Bachelor in Medical Technology from Universidad Mayor, Chile. Studying the role of RUBCNL in the immunomodulatory potential of mesenchymal stem cells.
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Felipe Court, Center for Integrative Biology, Universidad Mayor, Chile

Marcelo Garrido, Center for Precision Oncology, Universidad Mayor, Chile

Ignacio Retamal, Center for Precision Oncology, Universidad Mayor, Chile


Mathieu Bertrand, Inflammation Research Center, Ghent University, Ghent, Belgium

Gregory Buck, Center for Biological Complexity, Virginia Commonwealth University, Richmond, USA