Silva-Pavez E, Mendoza E, Morgado-Cáceres P, Ahumada-Castro U, Bustos G, Kangme-Encalada M, de Arbina AL, Puebla-Huerta A, Muñoz F, Cereceda L, Varas-Godoy M, Hidalgo Y, Cardenas JC. Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism. Sci Rep. 2024 Jun 19;14(1):14178. doi: 10.1038/s41598-024-64228-9.
Cortés BI, Meza RC, Ancatén-González C, Ardiles NM, Aránguiz MI, Tomita H, Kaplan DR, Cornejo F, Nunez-Parra A, Moya PR, Chávez AE, Cancino GI. Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice. Biol Res. 2024 Jun 18;57(1):40. doi: 10.1186/s40659-024-00522-0
Rojas-Rivera D, Beltrán S, Muñoz-Carvajal F, Ahumada-Montalva P, Abarzúa L, Gomez L, Hernandez F, Bergmann CA, Labrador L, Calegaro-Nassif M, Bertrand MJM, Manque PA, Woehlbier U. The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis. Autophagy. 2024 Jun 14. doi: 10.1080/15548627.2024.2367923
Acuña-Catalán D, Shah S, Wehrfritz C, Nomura M, Acevedo A, Olmos C, Quiroz G, Huerta H, Bons J, Ampuero E, Wyneken U, Sanhueza M, Arancibia F, Contreras D, Cárdenas JC, Morales B, Schilling B, Newman JC, González-Billault C. Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice. Cell Rep Med. 2024 Jun 3:101593. doi: 10.1016/j.xcrm.2024.101593
Catalán-Salas V, Sagredo P, Melgarejo W, Donoso MV, Cárdenas JC, Zakarian A, Valdés D, Acuña-Castillo C, Huidobro-Toro JP. 17-β-estradiol and phytoestrogens elicit NO production and vasodilatation through PI3K, PKA and EGF receptors pathways, evidencing functional selectivity. Eur J Pharmacol. 2024 Jul 15;975:176636. doi: 10.1016/j.ejphar.2024.176636
Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren., J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, J.W., Jones, Y. and Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science. 2024 May3;384(6695):573-579. doi: 10.1126/science.ade6970
Smith-Cortinez N, Heegsma J, Podunavac M, Zakarian A, Cardenas JC, Faber KN. Novel Inositol 1,4,5-Trisphosphate Receptor Inhibitor Antagonizes Hepatic Stellate Cell Activation: A Potential Drug to Treat Liver Fibrosis. Cells. 2024 Apr 30;13(9):765. doi: 10.3390/cells13090765
Hernández J, Panadero-Medianero C, Arrázola MS, Ahumada M. Mimicking the Physicochemical Properties of the Cornea: A Low-Cost Approximation Using Highly Available Biopolymers. Polymers (Basel). 2024 Apr 17;16(8):1118. doi: 10.3390/polym16081118
Alasaadi DN, Alvizi L, Hartmann J, Stillman N, Moghe P, Hiiragi T, Mayor R. Competence for neural crest induction is controlled by hydrostatic pressure through Yap. Nat Cell Biol. 2024 Apr;26(4):530-541. doi: 10.1038/s41556-024-01378-y
Faundes V, Repetto GM, Valdivia LE. Discovery of novel genetic syndromes in Latin America: Opportunities and challenges. Genet Mol Biol. 2024 Mar 11;47Suppl 1(Suppl 1):e20230318. doi: 10.1590/1678-4685-GMB-2023-0318
Cornejo F, Franchini N, Cortés BI, Elgueta D, Cancino GI. Neural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex. Front Cell Dev Biol. 2024 Feb 29;12:1357862. doi: 10.3389/fcell.2024.1357862
Cereceda L, Cardenas JC, Khoury M, Silva-Pavez E, Hidalgo Y. Impact of platelet-derived mitochondria transfer in the metabolic profiling and progression of metastatic MDA-MB-231 human triple-negative breast cancer cells. Front Cell Dev Biol. 2024 Jan 12;11:1324158. doi: 10.3389/fcell.2023.1324158
2023
Fuentes-Flores A, Geronimo-Olvera C, Girardi K, Necuñir-Ibarra D, Patel SK, Bons J, Wright MC, Geschwind D, Hoke A, Gomez-Sanchez JA, Schilling B, Rebolledo DL, Campisi J, Court FA. Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury. EMBO Mol Med. 2023 Dec 7;15(12):e17907. doi: 10.15252/emmm.202317907
Olivares GH, Olguín P. Editorial: The role of early-life nutrition and metabolism in brain development and adult behavior. Front Neurosci. 2023 Dec 18;17:1308183. doi: 10.3389/fnins.2023.1308183
Arcos J, Grunenwald F, Sepulveda D, Jerez C, Urbina V, Huerta T, Troncoso-Escudero P, Tirado D, Perez A, Diaz-Espinoza R, Nova E, Kubitscheck U, Rodriguez-Gatica JE, Hetz C, Toledo J, Ahumada P, Rojas-Rivera D, Martín-Montañez E, Garcia-Fernandez M, Vidal RL. IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models. Cell Death Discov. 2023 Dec 2;9(1):438. doi: 10.1038/s41420-023-01734-1
Gallicchio L, Olivares GH, Berry CW, Fuller MT. Regulation and function of alternative polyadenylation in development and differentiation. RNA Biol. 2023 Jan;20(1):908-925. doi: 10.1080/15476286.2023.2275109
Santos N, Valenzuela S, Segura C, Osorio-Roman I, Arrázola MS, Panadero-Medianero C, Santana PA, Ahumada M. Poly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performance. Discov Nano. 2023 Oct 17;18(1):129. doi: 10.1186/s11671-023-03907-4.
Sanhueza S, Vidal MA, Hernandez MA, Henriquez-Beltran ME, Cabrera C, Quiroga R, Antilef BE, Aguilar KP, Castillo DA, Llerena FJ, Fraga Figueroa M, Nazal M, Castro E, Lagos P, Moreno A, Lastra JJ, Gajardo J, Garcés P, Riffo B, Buchert J, Sanhueza R, Ormazába V, Saldivia P, Vargas C, Nourdin G, Koch E, Zuñiga FA, Lamperti L, Bustos P, Guzmán-Gutiérrez E, Tapia CA, Ferrada L, Cerda G, Woehlbier U, Riquelme E, Yuseff MI, Muñoz Ramirez BA, Lombardi G, De Gonzalo-Calvo D, Salomon C, Verdugo RA, Quiñones LA, Colombo A, Barría MI, Labarca G, Nova-Lamperti E. Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome. Front Med (Lausanne). 2023 Oct 6;10:1271863. doi: 10.3389/fmed.2023.1271863
Oyarce-Pezoa S, Rucatti GG, Muñoz-Carvajal F, Sanhueza N, Gomez W, Espinoza S, Leiva M, García N, Ponce DP, SanMartín CD, Rojas-Rivera D, Salvadores N, Behrens MI, Woehlbier U, Calegaro-Nassif M, Sanhueza M. The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains. Sci Rep. 2023 Oct 10;13(1):17137. doi: 10.1038/s41598-023-44203-6
Vega-Galvez A, Gomez-Perez LS, Zepeda F, Vidal RL, Grunenwald F, Mejías N, Pasten A, Araya M, Ah-Hen KS. Assessment of Bio-Compounds Content, Antioxidant Activity, and Neuroprotective Effect of Red Cabbage (Brassica oleracea var. Capitata rubra) Processed by Convective Drying at Different Temperatures. Antioxidants (Basel). 2023 Sep 21;12(9):1789. doi: 10.3390/antiox12091789.
Stillman NR, Mayor R. Generative models of morphogenesis in developmental biology. Semin Cell Dev Biol. 2023 Sep 30;147:83-90. doi: 10.1016/j.semcdb.2023.02.001
Candia N, Ibacache A, Medina-Yáñez I, Olivares GH, Ramírez M, Vega-Macaya F, Couve A, Sierralta J, Olguín P. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Hum Genet. 2023 Aug;142(8):1303-1315. doi: 10.1007/s00439-023-02577-7
Müller-Nedebock AC, Dekker MCJ, Farrer MJ, Hattori N, Lim SY, Mellick GD, Rektorová I, Salama M, Schuh AFS, Stoessl AJ, Sue CM, Tan AH, Vidal RL, Klein C, Bardien S. Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease. NPJ Parkinsons Dis. 2023 Jul 13;9(1):110. doi: 10.1038/s41531-023-00535-8. doi: 10.1038/s41531-023-00535-8
Arancibia-Opazo S, Contreras-Riquelme JS, Sánchez M, Cisternas-Olmedo M, Vidal RL, Martin AJM, Sáez MA. Transcriptional and Histone Acetylation Changes Associated with CRE Elements Expose Key Factors Governing the Regulatory Circuit in the Early Stage of Huntington's Disease Models. Int J Mol Sci. 2023 Jun 29;24(13):10848. doi: 10.3390/ijms241310848.
Tichauer JE, Arellano G, Acuña E, González LF, Kannaiyan NR, Murgas P, Panadero-Medianero C, Ibañez-Vega J, Burgos PI, Loda E, Miller SD, Rossner MJ, Gebicke-Haerter PJ, Naves R. Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia. Front Immunol. 2023 Jun 2;14:1191838. doi: 10.3389/fimmu.2023.1191838
Díaz-Jara E, Schwarz KG, Ríos-Gallardo A, Toledo C, Alcayaga JA, Court FA, Del Rio R. Carotid Body-Mediated Chemoreflex Function in Aging and the Role of Receptor-Interacting Protein Kinase. Adv Exp Med Biol. 2023;1427:195-201. doi: 10.1007/978-3-031-32371-3_21
Letelier J, Buono L, Almuedo-Castillo M, Zang J, Mounieres C, González-Díaz S, Polvillo R, Sanabria-Reinoso E, Corbacho J, Sousa-Ortega A, Diez Del Corral R, Neuhauss SCF, Martínez-Morales JR. Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. Elife. 2023 May 25;12:e85594.
Alvizi L, Nani D, Brito LA, Kobayashi GS, Passos-Bueno MR, Mayor R. Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction. Nat Commun. 2023 May 24;14(1):2868. doi: 10.1038/s41467-023-38526-1
Zúñiga-Hernández JM, Olivares GH, Olguín P, Glavic A. Low-nutrient diet in Drosophila larvae stage causes enhancement in dopamine modulation in adult brain due epigenetic imprinting. Open Biol. 2023 May;13(5):230049. doi: 10.1098/rsob.230049
Filadi R, De Mario A, Audano M, Romani P, Pedretti S, Cardenas C, Dupont S, Mammucari C, Mitro N, Pizzo P. Sustained IP3-linked Ca2+ signaling promotes progression of triple negative breast cancer cells by regulating fatty acid metabolism. Front Cell Dev Biol. 2023 Mar 13;11:1071037. doi: 10.3389/fcell.2023.1071037
Villablanca C, Vidal R, Gonzalez-Billault C. Are cytoskeleton changes observed in astrocytes functionally linked to aging? Brain Res Bull. 2023 May;196:59-67. doi: 10.1016/j.brainresbull.2023.03.007
Salazar C, Ferrés I, Paz M, Costábile A, Moratorio G, Moreno P, Iraola G. Fast and cost-effective SARS-CoV-2 variant detection using Oxford Nanopore full-length spike gene sequencing. Microb Genom. 2023 May;9(5):mgen001013. doi: 10.1099/mgen.0.001013.
Olivares GH, Núñez-Villegas F, Candia N, Oróstica K, González-Ramírez MC, Vega-Macaya F, Zúñiga N, Molina C, Oliva C, Mackay TFC, Verdugo RA, Olguín P. Early-life nutrition interacts with developmental genes to shape the brain and sleep behavior in Drosophila melanogaster. Sleep. 2023 Apr 12;46(4):zsad016. doi: 10.1093/sleep/zsad016
San Martin F, Fule L, Iraola G, Buschiazzo A, Picardeau M. Diving into the complexity of the spirochetal endoflagellum. Trends Microbiol. 2023 Mar;31(3):294-307. doi: 10.1016/j.tim.2022.09.010
Arrázola MS, Court FA. Commentary on "PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons". Neural Regen Res. 2023 Feb;18(2):341. doi: 10.1111/acel.13814
Pérez-Arancibia R, Cisternas-Olmedo M, Sepúlveda D, Troncoso-Escudero P, Vidal RL. Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics. Front Neurosci. 2023 Jan 9;16:1084493. doi: 10.3389/fnins.2022.1084493
Vega-Galvez A, Uribe E, Pasten A, Camus J, Gomez-Perez LS, Mejias N, Vidal RL, Grunenwald F, Aguilera LE, Valenzuela-Barra G. Comprehensive Evaluation of the Bioactive Composition and Neuroprotective and Antimicrobial Properties of Vacuum-Dried Broccoli (Brassica oleracea var. italica) Powder and Its Antioxidants. Molecules. 2023 Jan 12;28(2):766. doi: 10.3390/molecules28020766
2022
Marín T, Valls C, Jerez C, Huerta T, Elgueta D, Vidal RL, Alvarez AR, Cancino GI. The c-Abl/p73 pathway induces neurodegeneration in a Parkinson's disease model. IBRO Neurosci Rep. 2022 Oct 19;13:378-387. doi: 10.1016/j.ibneur.2022.10.006
Salazar C, Giménez M, Riera N, Parada A, Puig J, Galiana A, Grill F, Vieytes M, Mason CE, Antelo V, D'Alessandro B, Risso J, Iraola G. Human microbiota drives hospital-associated antimicrobial resistance dissemination in the urban environment and mirrors patient case rates. Microbiome. 2022 Dec 2;10(1):208. doi: 10.1186/s40168-022-01407-8
Rosso AD, Aguilera P, Quesada S, Mascardi F, Mascuka SN, Cimolai MC, Cerezo J, Spiazzi R, Conlon C, Milano C, Iraola GM, Penas-Steinhardt A, Belforte FS. Comprehensive Phenotyping in Inflammatory Bowel Disease: Search for Biomarker Algorithms in the Transkingdom Interactions Context. Microorganisms. 2022 Nov 4;10(11):2190. doi: 10.3390/microorganisms10112190
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. EMBO J. 2022 Nov 17;41(22):e111952. doi: 10.15252/embj.2022111952
Li Y, Paola E, Wang Z, Menard G, Zakarian A. Lithium Enolate with a Lithium-Alkyne Interaction in the Enantioselective Construction of Quaternary Carbon Centers: Concise Synthesis of (+)-Goniomitine. Angew Chem Int Ed Engl. 2022 Nov 14;61(46):e202209987. doi: 10.1002/anie.202209987
Saquel C, Catalan RJ, Lopez-Leal R, Ramirez RA, Necuñir D, Wyneken U, Lamaze C, Court FA. Neuronal activity-dependent ATP enhances the pro-growth effect of repair Schwann cell extracellular vesicles by increasing their miRNA-21 loading. Front Cell Neurosci. 2022 Sep 23;16:943506. doi: 10.3389/fncel.2022.943506
Kline RA, Lößlein L, Kurian D, Aguilar Martí J, Eaton SL, Court FA, Gillingwater TH, Wishart TM. An Optimized Comparative Proteomic Approach as a Tool in Neurodegenerative Disease Research. Cells. 2022 Aug 26;11(17):2653. doi: 10.3390/cells11172653
Morgado-Cáceres P, Liabeuf G, Calle X, Briones L, Riquelme JA, Bravo-Sagua R, Parra V. The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells. Front Cell Dev Biol. 2022 Aug 19;10:946678. doi: 10.3389/fcell.2022.946678
Salazar C, Antelo V, Vieytes M, Dávila C, Grill F, Galiana A, Iraola G. First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America. J Glob Antimicrob Resist. 2022 Sep;30:480-484. doi: 10.1016/j.jgar.2022.08.005
Vasini B, Farace P, Ariel A, Cirone K, Mendez L, Morsella C, Fresia P, Iraola G, Gioffré A, Paolicchi F. Phylogenetic and Multiple-Locus Variable number tandem repeat analysis of Mycobacterium avium subsp. paratuberculosis isolates from Argentina. Vet Res Commun. 2022 Dec;46(4):1121-1129. doi: 10.1007/s11259-022-09983-8
Espinoza S, Grunenwald F, Gomez W, García F, Abarzúa-Catalan L, Oyarce-Pezoa S, Hernandez MF, Cortés BI, Uhrig M, Ponce DP, Durán-Aniotz C, Hetz C, SanMartín CD, Cornejo VH, Ezquer F, Parra V, Behrens MI, Manque PA, Rojas-Rivera D, Vidal RL, Woehlbier U, Nassif M. Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer's Disease. Cells. 2022 Jun 7;11(12):1860. doi: 10.3390/cells11121860
Turner KJ, Hawkins TA, Henriques PM, Valdivia LE, Bianco IH, Wilson SW, Folgueira M. A Structural Atlas of the Developing Zebrafish Telencephalon Based on Spatially-Restricted Transgene Expression. Front Neuroanat. 2022 Jun 1;16:840924. doi: 10.3389/fnana.2022.840924
Bergmann CA, Beltran S, Vega-Letter AM, Murgas P, Hernandez MF, Gomez L, Labrador L, Cortés BI, Poblete C, Quijada C, Carrion F, Woehlbier U, Manque PA. The Autophagy Protein Pacer Positively Regulates the Therapeutic Potential of Mesenchymal Stem Cells in a Mouse Model of DSS-Induced Colitis. Cells. 2022 Apr 30;11(9):1503. doi: 10.3390/cells11091503
Tuschl K, White RJ, Trivedi C, Valdivia LE, Niklaus S, Bianco IH, Dadswell C, González-Méndez R, Sealy IM, Neuhauss SCF, Houart C, Rihel J, Wilson SW, Busch-Nentwich EM. Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish. Dis Model Mech. 2022 Jun 1;15(6):dmm044594. doi: 10.1242/dmm.044594
Correa-Burrows P, Burrows R, Albala C, Court FA, Salech F, Sanhueza G, Gonzalez-Billault C. Multiple events case-control study in a prospective cohort to identify systemic, cellular, and molecular biomarkers of obesity-induced accelerated aging in 30-years-olds: the ObAGE study protocol. BMC Geriatr. 2022 May 2;22(1):387. doi: 10.1186/s12877-022-03032-4
Elgueta D, Murgas P, Riquelme E, Yang G, Cancino GI. Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring. Front Immunol. 2022 Apr 7;13:816619. doi: 10.3389/fimmu.2022.816619
Aguilera P, Mascardi MF, Belforte FS, Rosso AD, Quesada S, Llovet I, Iraola G, Trinks J, Penas-Steinhardt A. A Two-Time Point Analysis of Gut Microbiota in the General Population of Buenos Aires and Its Variation Due to Preventive and Compulsory Social Isolation During the COVID-19 Pandemic. Front Microbiol. 2022 Mar 24;13:803121. doi: 10.3389/fmicb.2022.803121
Abdel Aziz K, Herane-Vives A, Stip E, Arnone D. Editorial: Novel Approaches to Improve Detection, Differentiation and Treatment in Mood Disorders. Front Psychiatry. 2022 Mar 4;13:837283. doi: 10.3389/fpsyt.2022.837283
Salvadores N, Moreno-Gonzalez I, Gamez N, Quiroz G, Vegas-Gomez L, Escandón M, Jimenez S, Vitorica J, Gutierrez A, Soto C, Court FA. Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer's disease. Acta Neuropathol Commun. 2022 Mar 9;10(1):31. doi: 10.1186/s40478-022-01332-9
Sepúlveda D, Cisternas-Olmedo M, Arcos J, Nassif M, Vidal RL. Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson's Disease. Front Mol Neurosci. 2022 Feb 17;15:805087. doi: 10.3389/fnmol.2022.805087
Sepúlveda D, Grunenwald F, Vidal A, Troncoso-Escudero P, Cisternas-Olmedo M, Villagra R, Vergara P, Aguilera C, Nassif M, Vidal RL. Insulin-like growth factor 2 and autophagy gene expression alteration arise as potential biomarkers in Parkinson's disease. Sci Rep. 2022 Feb 7;12(1):2038. doi: 10.1038/s41598-022-05941-1
Venegas-Zamora L, Bravo-Acuña F, Sigcho F, Gomez W, Bustamante-Salazar J, Pedrozo Z, Parra V. New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease. Front Genet. 2022 Jan 18;12:792231. doi: 10.3389/fgene.2021.792231
Ortiz JA, Sepúlveda FA, Panadero-Medianero C, Murgas P, Ahumada M, Palza H, Matsuhiro B, Zapata PA. Cytocompatible drug delivery hydrogels based on carboxymethylagarose/chitosan pH-responsive polyelectrolyte complexes. Int J Biol Macromol. 2022 Feb 28;199:96-107. doi: 10.1016/j.ijbiomac.2021.12.093
Bilches Medinas D, Malik S, Yıldız-Bölükbaşı E, Borgonovo J, Saaranen MJ, Urra H, Pulgar E, Afzal M, Contreras D, Wright MT, Bodaleo F, Quiroz G, Rozas P, Mumtaz S, Díaz R, Rozas C, Cabral-Miranda F, Piña R, Valenzuela V, Uyan O, Reardon C, Woehlbier U, Brown RH, Sena-Esteves M, Gonzalez-Billault C, Morales B, Plate L, Ruddock LW, Concha ML, Hetz C, Tolun A. Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis. EMBO J. 2022 Dec 17;41(2):e105531. doi: 10.15252/embj.2020105531
Wu J, Danko D, Afshinnekoo E, Bezdan D, Bhattacharyya M, Castro-Nallar E, Chmielarczyk A, Hazrin-Chong NH, Deng Y, Dias-Neto E, Frolova A, Mason-Buck G, Iraola G, Jang S, Łabaj P, Lee PKH, Nieto-Caballero M, Osuolale OO, Ouzounis CA, Perlin MH, Prithiviraj B, Rascovan N, Różańska A, Schriml LM, Semmler T, Suzuki H, Ugalde JA, Young B, Werner J, Zambrano MM, Zhao Y, Mason C, Shi T; MetaSUB Consortium. Annotating unknown species of urban microorganisms on a global scale unveils novel functional diversity and local environment association. Environ Res. 2022 May 1;207:112183. doi: 10.1016/j.envres.2021.112183
2021
Ferrés I, Iraola G. An object-oriented framework for evolutionary pangenome analysis. Cell Rep Methods. 2021 Sep 27;1(5):100085. doi: 10.1016/j.crmeth.2021.100085
Cornejo F, Cortés BI, Findlay GM, Cancino GI. LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain. Front Cell Dev Biol. 2021 Dec 13;9:659951. doi: 10.3389/fcell.2021.659951
Gudenschwager C, Chavez I, Cardenas C, Gonzalez-Billault C. Directly Reprogrammed Human Neurons to Understand Age-Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration. Oxid Med Cell Longev. 2021 Dec 14;2021:5586052. doi: 10.1155/2021/5586052
Muñoz D, Fuentes R, Carnicero B, Aguilar A, Sanhueza N, San-Martin S, Agurto C, Donoso A, Valdivia LE, Miguez JM, Tort L, Boltana S. Viral Infection Drives the Regulation of Feeding Behavior Related Genes in Salmo salar. Int J Mol Sci. 2021 Oct 21;22(21):11391. doi: 10.3390/ijms222111391
Letelier J, Naranjo S, Sospedra-Arrufat I, Martinez-Morales JR, Lopez-Rios J, Shubin N, Gómez-Skarmeta JL. The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits. Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2100575118. doi: 10.1073/pnas.2100575118
Farfán N, Sanhueza N, Briones M, Burzio LO, Burzio VA. Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro. Biol Res. 2021 Oct 19;54(1):33. doi: 10.1186/s40659-021-00356-0
Ferrés I, Iraola G. Protocol for post-processing of bacterial pangenome data using Pagoo pipeline. STAR Protoc. 2021 Sep 29;2(4):100802. doi: 10.1016/j.xpro.2021.100802
Rego N, Salazar C, Paz M, Costábile A, Fajardo A, Ferrés I, Perbolianachis P, Fernández-Calero T, Noya V, Machado MR, Brandes M, Arce R, Arleo M, Possi T, Reyes N, Bentancor MN, Lizasoain A, Bortagaray V, Moller A, Chappos O, Nin N, Hurtado J, Duquía M, González MB, Griffero L, Méndez M, Techera MP, Zanetti J, Pereira E, Rivera B, Maidana M, Alonso M, Smircich P, Arantes I, Mir D, Alonso C, Medina J, Albornoz H, Colina R, Bello G, Moreno P, Moratorio G, Iraola G, Spangenberg L. Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay.Viruses. 2021 Sep 10;13(9):1801. doi: 10.3390/v13091801
Riquelme E, McAllister F. Bacteria and fungi: The counteracting modulators of immune responses to radiation therapy in cancer. Cancer Cell. 2021 Sep 13;39(9):1173-1175. doi: 10.1016/j.ccell.2021.08.004
Gorostieta-Salas E, Moreno-Blas D, Gerónimo-Olvera C, Cisneros B, Court FA, Castro-Obregón S. Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain. Oxid Med Cell Longev. 2021 Aug 13;2021:6682336. doi: 10.1155/2021/6682336
Peña OA, Lubin A, Hockings C, Rowell J, Jung Y, Hoade Y, Dace P, Valdivia LE, Tuschl K, Böiers C, Virgilio MC, Richardson S, Payne EM. TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signaling. Blood Adv. 2021 Oct 26;5(20):4112-4124. doi: 10.1182/bloodadvances.2020003055
Cuesta-Astroz Y, Gischkow Rucatti G, Murgas L, SanMartín CD, Sanhueza M, Martin AJM. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Front Genet. 2021 Jul 28;12:649764. doi: 10.3389/fgene.2021.649764
Bustos G, Ahumada-Castro U, Silva-Pavez E, Puebla A, Lovy A, Cesar Cardenas J. The ER-mitochondria Ca2+ signaling in cancer progression: Fueling the monster. Int Rev Cell Mol Biol. 2021;363:49-121. doi: 10.1016/bs.ircmb.2021.03.006
Pérez-Arancibia R, Ordoñez JL, Rivas A, Pihán P, Sagredo A, Ahumada U, Barriga A, Seguel I, Cárdenas C, Vidal RL, Hetz C, Delporte C. A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington's disease. PLoS One. 2021 Jul 29;16(7):e0254834. doi: 10.1371/journal.pone.0254834
Ahumada-Castro U, Puebla-Huerta A, Cuevas-Espinoza V, Lovy A, Cardenas JC. Keeping zombies alive: The ER-mitochondria Ca2+ transfer in cellular senescence. Biochim Biophys Acta Mol Cell Res. 2021 Oct;1868(11):119099
Gómora-García JC, Gerónimo-Olvera C, Pérez-Martínez X, Massieu L. IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation. Cell Death Discov. 2021 Jun 3;7(1):131. doi: 10.1038/s41420-021-00518-9
Danko D, Bezdan D, Afshin EE, Ahsanuddin S, Bhattacharya C, Butler DJ, Chng KR, Donnellan D, Hecht J, Jackson K, Kuchin K, Karasikov M, Lyons A, Mak L, Meleshko D, Mustafa H, Mutai B, Neches RY, Ng A, Nikolayeva O, Nikolayeva T, Png E, Ryon KA, Sanchez JL, Shaaban H, Sierra MA, Thomas D, Young B, Abudayyeh OO, Alicea J, Bhattacharyya M, Blekhman R, Castro-Nallar E, Cañas AM, Chatziefthimiou AD, Crawford RW, De Filippis F, Deng Y, Desnues C, Dias-Neto E, Dybwad M, Elhaik E, Ercolini D, Frolova A, Gankin D, Gootenberg JS, Graf AB, Green DC, Hajirasouliha I, Hastings JJA, Hernandez M, Iraola G, Jang S, Kahles A, Kelly FJ, Knights K, Kyrpides NC, Łabaj PP, Lee PKH, Leung MHY, Ljungdahl PO, Mason-Buck G, McGrath K, Meydan C, Mongodin EF, Moraes MO, Nagarajan N, Nieto-Caballero M, Noushmehr H, Oliveira M, Ossowski S, Osuolale OO, Özcan O, Paez-Espino D, Rascovan N, Richard H, Rätsch G, Schriml LM, Semmler T, Sezerman OU, Shi L, Shi T, Siam R, Song LH, Suzuki H, Court DS, Tighe SW, Tong X, Udekwu KI, Ugalde JA, Valentine B, Vassilev DI, Vayndorf EM, Velavan TP, Wu J, Zambrano MM, Zhu J, Zhu S, Mason CE; International MetaSUB Consortium.A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell. 2021 Jun 24;184(13):3376-3393.e17. doi: 10.1016/j.cell.2021.05.002
López-Domínguez JA, Rodríguez-López S, Ahumada-Castro U, Desprez PY, Konovalenko M, Laberge RM, Cárdenas C, Villalba JM, Campisi J. Cdkn1a transcript variant 2 is a marker of aging and cellular senescence. Aging (Albany NY). 2021 May 25;13(10):13380-13392. doi: 10.18632/aging.203110
Ramos-Fernández E, Arrázola MS, Oliva CA, Arredondo SB, Varela-Nallar L, Inestrosa NC. Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase. Sci Rep. 2021 Apr 1;11(1):7395. doi: 10.1038/s41598-021-86708-y
Podunavac M, Mailyan AK, Jackson JJ, Lovy A, Farias P, Huerta H, Molgó J, Cardenas C, Zakarian A. Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival. Angew Chem Int Ed Engl. 2021 May 10;60(20):11278-11282. doi: 10.1002/anie.202102259
Ahumada-Castro U, Bustos G, Silva-Pavez E, Puebla-Huerta A, Lovy A, Cárdenas C. In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes. Front Cell Dev Biol. 2021 Mar 2;9:629522. doi: 10.3389/fcell.2021.629522
Briceño P, Rivas-Yañez E, Rosemblatt MV, Parra-Tello B, Farías P, Vargas L, Simon V, Cárdenas C, Lladser A, Salazar-Onfray F, Elorza AA, Rosemblatt M, Bono MR, Sauma D. CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity. Front Cell Dev Biol. 2021 Feb 18;9:638037. doi: 10.3389/fcell.2021.638037
Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280
Parra MA, Baez S, Sedeño L, Gonzalez Campo C, Santamaría-García H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, de Souza LC, Custodio N, Damian A, de la Cruz M, Diehl Rodriguez R, Brucki SMD, Fajersztajn L, Farías GA, De Felice FG, Ferrari R, de Oliveira FF, Ferreira ST, Ferretti C, Figueredo Balthazar ML, Ferreira Frota NA, Fuentes P, García AM, Garcia PJ, de Gobbi Porto FH, Duque Peñailillo L, Engler HW, Maier I, Mata IF, Gonzalez-Billault C, Lopez OL, Morelli L, Nitrini R, Quiroz YT, Guerrero Barragan A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Miller B, Mansur LL, Hosogi ML, Lillo P, Llibre Guerra J, Lira D, Lopera F, Comas A, Avila-Funes JA, Sosa AL, Ramos C, Resende EPF, Snyder HM, Tarnanas I, Yokoyama J, Llibre J, Cardona JF, Possin K, Kosik KS, Montesinos R, Moguilner S, Solis PCL, Ferretti-Rebustini REL, Ramirez JM, Matallana D, Mbakile-Mahlanza L, Marques Ton AM, Tavares RM, Miotto EC, Muniz-Terrera G, Muñoz-Nevárez LA, Orozco D, Okada de Oliveira M, Piguet O, Pintado Caipa M, Piña Escudero SD, Schilling LP, Rodrigues Palmeira AL, Yassuda MS, et al. Dementia in Latin America: Paving the way toward a regional action plan. Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202
Barrera-Avalos C, Díaz X, Madrid B, Michelson SA, Robles-Planells C, Sánchez-Guerrero G, Ahumada V, Mella-Torres A, Rojo LE, Imarai M, Milla LA, Leiva-Salcedo E, Murgas P, Fernández R, Escobar A, Acuña-Castillo C. In Vivo Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma by Autologous Whole Tumor Dead Cells. Biomed Res Int. 2021 Feb 3;2021:6626851. doi: 10.1155/2021/6626851
Leyton E, Matus D, Espinoza S, Benitez JM, Cortés BI, Gomez W, Arévalo NB, Murgas P, Manque P, Woehlbier U, Duran-Aniotz C, Hetz C, Behrens MI, SanMartín CD, Nassif M. DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease. J Alzheimers Dis. 2021;82(s1):S163-S178. doi: 10.3233/JAD-201264
Costa D, Lévesque S, Kumar N, Fresia P, Ferrés I, Lawley TD, Iraola G. Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts. Sci Rep. 2021 Feb 9;11(1):3431. doi: 10.1038/s41598-021-82993-9
Silva-Pavez E, Ahumada-Castro U, Lovy A, Cárdenas JC. Ca2+ transfer to mitochondria: a spark of life in unexpected conditions. Mol Cell Oncol. 2020 Dec 15;8(1):1839341. doi: 10.1080/23723556.2020.1839341
Vidal RL, Sepulveda D, Troncoso-Escudero P, Garcia-Huerta P, Gonzalez C, Plate L, Jerez C, Canovas J, Rivera CA, Castillo V, Cisternas M, Leal S, Martinez A, Grandjean J, Sonia D, Lashuel HA, Martin AJM, Latapiat V, Matus S, Sardi SP, Wiseman RL, Hetz C. Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration. Mol Ther. 2021 May 5;29(5):1862-1882. doi: 10.1016/j.ymthe.2021.01.033
Castillo F, Monasterio G, Ibarra JP, Guevara J, Cafferata EA, Vicencio E, Cortez C, Carvajal P, Vernal R. Levels of low-molecular-weight hyaluronan in periodontitis-treated patients and its immunostimulatory effects on CD4+ T lymphocytes. Clin Oral Investig. 2021 Aug;25(8):4987-5000. doi: 10.1007/s00784-021-03808-9
Lemaitre D, Court FA. New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury. Neural Regen Res. 2021 Sep;16(9):1760-1761. doi: 10.4103/1673-5374.306069
Delpiazzo R, Barcellos M, Barros S, Betancor L, Fraga M, Gil J, Iraola G, Morsella C, Paolicchi F, Pérez R, Riet-Correa F, Sanguinetti M, Silva A, da Silva Silveira C, Calleros L. Accurate and fast identification of Campylobacter fetus in bulls by real-time PCR targeting a 16S rRNA gene sequence. Vet Anim Sci. 2020 Dec 24;11:100163. doi: 10.1016/j.vas.2020.100163
Cruz P, Ahumada-Castro U, Bustos G, Molgó J, Sauma D, Lovy A, Cárdenas C. Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells. Int J Mol Sci. 2021 Jan 11;22(2):651. doi: 10.3390/ijms22020651
Arévalo NB, Castillo-Godoy DP, Espinoza-Fuenzalida I, Rogers NK, Farias G, Delgado C, Henriquez M, Herrera L, Behrens MI, SanMartín CD. Association of Vitamin D Receptor Polymorphisms with Amyloid-β Transporters Expression and Risk of Mild Cognitive Impairment in a Chilean Cohort. J Alzheimers Dis. 2021;82(s1):S283-S297. doi: 10.3233/JAD-201031
Cafferata EA, Castro-Saavedra S, Fuentes-Barros G, Melgar-Rodríguez S, Rivera F, Carvajal P, Hernández M, Cortés BI, Cortez C, Cassels BK, Vernal R. Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance. J Periodontol. 2021 Jan;92(1):123-136. doi: 10.1002/JPER.20-0055
2020
Slachevsky A, Zitko P, Martínez-Pernía D, Forno G, Court FA, Lillo P, Villagra R, Duran-Aniotz C, Parrao T, Assar R, Orellana P, Toledo C, Rivera R, Ibañez A, Parra MA, González-Billault C, Amieva H, Thumala D. GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly. BMC Geriatr. 2020 Nov 25;20(1):505. doi: 10.1186/s12877-020-01866-4
Basualto-Alarcón C, Urra FA, Bozán MF, Jaña F, Trangulao A, Bevilacqua JA, Cárdenas JC. Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function. PLoS One. 2020 Nov 20;15(11):e0242443. doi: 10.1371/journal.pone.0242443
Salvadores N, Gerónimo-Olvera C, Court FA. Axonal Degeneration in AD: The Contribution of Aβ and Tau. Front Aging Neurosci. 2020 Oct 15;12:581767. doi: 10.3389/fnagi.2020.581767
Troncoso-Escudero P, Sepulveda D, Pérez-Arancibia R, Parra AV, Arcos J, Grunenwald F, Vidal RL. On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease. Front Aging Neurosci. 2020 Sep 3;12:571185. doi: 10.3389/fnagi.2020.571185
Muñoz-Carvajal F, Sanhueza M. The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging. Front Aging Neurosci. 2020 Sep 11;12:581849. doi: 10.3389/fnagi.2020.581849
Wisniewski L, French V, Lockwood N, Valdivia LE, Frankel P. P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis. Sci Rep. 2020 Sep 24;10(1):15589. doi: 10.1038/s41598-020-71753-w
Salech F, Ponce DP, Paula-Lima AC, SanMartin CD, Behrens MI. Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease. Front Aging Neurosci. 2020 Aug 13;12:255. doi: 10.3389/fnagi.2020.00255
Zhang Y, Chandra V, Riquelme Sanchez E, Dutta P, Quesada PR, Rakoski A, Zoltan M, Arora N, Baydogan S, Horne W, Burks J, Xu H, Hussain P, Wang H, Gupta S, Maitra A, Bailey JM, Moghaddam SJ, Banerjee S, Sahin I, Bhattacharya P, McAllister F. Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med. 2020 Dec 7;217(12):e20190354. doi: 10.1084/jem.20190354
Pérez-Moreno P, Quezada-Meza C, Chavez-Almarza C, Niechi I, Silva-Pavez E, Trigo-Hidalgo C, Aguayo F, Jara L, Cáceres-Verschae A, Varas-Godoy M, Díaz VM, García de Herreros A, Burzio VA, Tapia JC. Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells. Front Oncol. 2020 Jul 30;10:1004. doi: 10.3389/fonc.2020.01004
Lemaitre D, Hurtado ML, De Gregorio C, Oñate M, Martínez G, Catenaccio A, Wishart TM, Court FA. Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile. Mol Neurobiol. 2020 Oct;57(10):4232-4249. doi: 10.1007/s12035-020-01986-3
Cardenas C, Lovy A, Silva-Pavez E, Urra F, Mizzoni C, Ahumada-Castro U, Bustos G, Jaňa F, Cruz P, Farias P, Mendoza E, Huerta H, Murgas P, Hunter M, Rios M, Cerda O, Georgakoudi I, Zakarian A, Molgó J, Foskett JK. Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival. Sci Signal. 2020 Jul 14;13(640):eaay1212. doi: 10.1126/scisignal.aay1212
López-Leal R, Court FA. Ex Vivo Analysis of Axonal Degeneration Using Sciatic and Optic Nerve Preparations. Methods Mol Biol. 2020;2143:179-189. doi: 10.1007/978-1-0716-0585-1_14
Lovy A, Ahumada-Castro U, Bustos G, Farias P, Gonzalez-Billault C, Molgó J, Cardenas C. Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca2+ Transfer to Mitochondria. Front Cell Dev Biol. 2020 May 25;8:378. doi: 10.3389/fcell.2020.00378
Ostria-Gallardo E, Larama G, Berríos G, Fallard A, Gutiérrez-Moraga A, Ensminger I, Manque P, Bascuñán-Godoy L, Bravo LA. Decoding Gene Networks Modules That Explain the Recovery of Hymenoglossum cruentum Cav. After Extreme Desiccation. Front Plant Sci. 2020 May 15;11:574. doi: 10.3389/fpls.2020.00574
Cafferata EA, Castro-Saavedra S, Fuentes-Barros G, Melgar-Rodríguez S, Rivera F, Carvajal P, Hernández M, Cortés BI, Cortez C, Cassels BK, Vernal R. Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance. J Periodontol. 2021 Jan;92(1):123-136. doi: 10.1002/JPER.20-0055
Martinez NW, Sánchez A, Diaz P, Broekhuizen R, Godoy J, Mondaca S, Catenaccio A, Macanas P, Nervi B, Calvo M, Court FA. Metformin protects from oxaliplatin induced peripheral neuropathy in rats. Neurobiol Pain. 2020 May 22;8:100048. doi: 10.1016/j.ynpai.2020.100048
Vicencio E, Cordero EM, Cortés BI, Palominos S, Parra P, Mella T, Henrríquez C, Salazar N, Monasterio G, Cafferata EA, Murgas P, Vernal R, Cortez C. Aggregatibacter Actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes. Cells. 2020 May 14;9(5):1221. doi: 10.3390/cells9051221
López-Leal R, Díaz-Viraqué F, Catalán RJ, Saquel C, Enright A, Iraola G, Court FA. Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth. J Cell Sci. 2020 Jun 15;133(12):jcs239004. doi: 10.1242/jcs.239004
Salvadores N, Court FA. The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade? Expert Opin Ther Targets. 2020 Jul;24(7):679-693. doi: 10.1080/14728222.2020.1758668
Vicencio E, Beltrán S, Labrador L, Manque P, Nassif M, Woehlbier U. Implications of Selective Autophagy Dysfunction for ALS Pathology. Cells. 2020 Feb 7;9(2):381. doi: 10.3390/cells9020381
Montecinos-Oliva C, Arrázola MS, Jara C, Tapia-Rojas C, Inestrosa NC. Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation. Pharmaceuticals (Basel). 2020 Feb 2;13(2):24. doi: 10.3390/ph13020024
Rodríguez M, Ceric F, Murgas P, Harland B, Torrealba F, Contreras M. Interoceptive Insular Cortex Mediates Both Innate Fear and Contextual Threat Conditioning to Predator Odor. Front Behav Neurosci. 2020 Jan 9;13:283. doi: 10.3389/fnbeh.2019.00283
De Luca C, Iraola G, Apostolakos I, Boetto E, Piccirillo A. Occurrence and diversity of Campylobacter species in captive chelonians. Vet Microbiol. 2020 Feb;241:108567. doi: 10.1016/j.vetmic.2019.108567
Gomez W, Morales R, Maracaja-Coutinho V, Parra V, Nassif M. Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein. Aging (Albany NY). 2020 Jan 9;12(1):1011-1033. doi: 10.18632/aging.102677
Tomita H, Cornejo F, Aranda-Pino B, Woodard CL, Rioseco CC, Neel BG, Alvarez AR, Kaplan DR, Miller FD, Cancino GI. The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis. Cell Rep. 2020 Jan 7;30(1):215-228.e5. doi: 10.1016/j.celrep.2019.11.033
Rogers NK, Romero C, SanMartín CD, Ponce DP, Salech F, López MN, Gleisner A, Tempio F, Behrens MI. Inverse Relationship Between Alzheimer's Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases. J Alzheimers Dis. 2020;73(2):443-454. doi: 10.3233/JAD-190839
SanMartín CD, Böhme D, Rojas-Rivera D. Calcium & ROS: Two orchestra directors for the requiem of death. Cell Calcium. 2020 Jan;85:102113. doi: 10.1016/j.ceca.2019.102113
Krabbendam IE, Honrath B, Bothof L, Silva-Pavez E, Huerta H, Peñaranda Fajardo NM, Dekker F, Schmidt M, Culmsee C, César Cárdenas J, Kruyt F, Dolga AM. SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells. Biochem Pharmacol. 2020 Jan;171:113714. doi: 10.1016/j.bcp.2019.113714
Oñate M, Catenaccio A, Salvadores N, Saquel C, Martinez A, Moreno-Gonzalez I, Gamez N, Soto P, Soto C, Hetz C, Court FA. The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. Cell Death Differ. 2020 Apr;27(4):1169-1185. doi: 10.1038/s41418-019-0408-4
Ferrés I, Fresia P, Iraola G. simurg: simulate bacterial pangenomes in R. Bioinformatics. 2020 Feb 15;36(4):1273-1274. doi: 10.1093/bioinformatics/btz735
Costa D, Betancor L, Gadea P, Cabezas L, Caiata L, Palacio R, Seija V, Galiana A, Vieytes M, Cristophersen I, Calleros L, Iraola G. Polyclonal Campylobacter fetus Infections Among Unrelated Patients, Montevideo, Uruguay, 2013-2018. Clin Infect Dis. 2020 Mar 3;70(6):1236-1239. doi: 10.1093/cid/ciz657
2019
Nieves C, Ferrés I, Díaz-Viraqué F, Buschiazzo A, Zarantonelli L, Iraola G. Draft Genome Sequences of 40 Pathogenic Leptospira Strains Isolated from Cattle in Uruguay. Microbiol Resour Announc. 2019 Nov 21;8(47):e00893-19. doi: 10.1128/MRA.00893-19
Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP. The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability. Acta Neuropathol Commun. 2019 Sep 12;7(1):147. doi: 10.1186/s40478-019-0802-7
Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, Quesada P, Sahin I, Chandra V, San Lucas A, Scheet P, Xu H, Hanash SM, Feng L, Burks JK, Do KA, Peterson CB, Nejman D, Tzeng CD, Kim MP, Sears CL, Ajami N, Petrosino J, Wood LD, Maitra A, Straussman R, Katz M, White JR, Jenq R, Wargo J, McAllister F. Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell. 2019 Aug 8;178(4):795-806.e12. doi: 10.1016/j.cell.2019.07.008
Muñoz M, Restrepo-Montoya D, Kumar N, Iraola G, Camargo M, Díaz-Arévalo D, Roa-Molina NS, Tellez MA, Herrera G, Ríos-Chaparro DI, Birchenall C, Pinilla D, Pardo-Oviedo JM, Rodríguez-Leguizamón G, Josa DF, Lawley TD, Patarroyo MA, Ramírez JD. Integrated genomic epidemiology and phenotypic profiling of Clostridium difficile across intra-hospital and community populations in Colombia. Sci Rep. 2019 Aug 5;9(1):11293. doi: 10.1038/s41598-019-47688-2
Jaña F, Bustos G, Rivas J, Cruz P, Urra F, Basualto-Alarcón C, Sagredo E, Ríos M, Lovy A, Dong Z, Cerda O, Madesh M, Cárdenas C. Complex I and II are required for normal mitochondrial Ca2+ homeostasis. Mitochondrion. 2019 Nov;49:73-82. doi: 10.1016/j.mito.2019.07.004
Muñoz M, Restrepo-Montoya D, Kumar N, Iraola G, Herrera G, Ríos-Chaparro DI, Díaz-Arévalo D, Patarroyo MA, Lawley TD, Ramírez JD. Comparative genomics identifies potential virulence factors in Clostridium tertium and C. paraputrificum. Virulence. 2019 Dec;10(1):657-676. doi: 10.1080/21505594.2019.1637699
Costa D, Iraola G. Pathogenomics of Emerging Campylobacter Species. Clin Microbiol Rev. 2019 Jul 3;32(4):e00072-18. doi: 10.1128/CMR.00072-18
Díaz-Viraqué F, Pita S, Greif G, de Souza RCM, Iraola G, Robello C. Nanopore Sequencing Significantly Improves Genome Assembly of the Protozoan Parasite Trypanosoma cruzi. Genome Biol Evol. 2019 Jul 1;11(7):1952-1957. doi: 10.1093/gbe/evz129
Kline RA, Dissanayake KN, Hurtado ML, Martínez NW, Ahl A, Mole AJ, Lamont DJ, Court FA, Ribchester RR, Wishart TM, Murray LM. Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice. Neurobiol Dis. 2019 Oct;130:104496. doi: 10.1016/j.nbd.2019.104496
Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C. Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol. 2019 Jun;21(6):755-767. doi: 10.1038/s41556-019-0329-y
Monasterio G, Budini V, Fernández B, Castillo F, Rojas C, Alvarez C, Cafferata EA, Vicencio E, Cortés BI, Cortez C, Vernal R. IL-22-expressing CD4+ AhR+ T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis. J Periodontal Res. 2019 Oct;54(5):513-524. doi: 10.1111/jre.12654
Chao de la Barca JM, Arrázola MS, Bocca C, Arnauné-Pelloquin L, Iuliano O, Tcherkez G, Lenaers G, Simard G, Belenguer P, Reynier P. The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling. Sci Rep. 2019 Apr 15;9(1):6107. doi: 10.1038/s41598-019-42554-7
Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC. c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Sci Rep. 2019 Apr 15;9(1):6070. doi: 10.1038/s41598-019-42420-6
Arrazola MS, Court FA. Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology. Neural Regen Res. 2019 Aug;14(8):1385-1386. doi: 10.4103/1673-5374.253520
Beltran S, Nassif M, Vicencio E, Arcos J, Labrador L, Cortes BI, Cortez C, Bergmann CA, Espinoza S, Hernandez MF, Matamala JM, Bargsted L, Matus S, Rojas-Rivera D, Bertrand MJM, Medinas DB, Hetz C, Manque PA, Woehlbier U. Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis. Mol Neurodegener. 2019 Mar 27;14(1):14. doi: 10.1186/s13024-019-0313-9
Gerónimo-Olvera C, Massieu L. Autophagy as a Homeostatic Mechanism in Response to Stress Conditions in the Central Nervous System. Mol Neurobiol. 2019 Sep;56(9):6594-6608. doi: 10.1007/s12035-019-1546-x
Arrázola MS, Saquel C, Catalán RJ, Barrientos SA, Hernandez DE, Martínez NW, Catenaccio A, Court FA. Axonal Degeneration Is Mediated by Necroptosis Activation. J Neurosci. 2019 May 15;39(20):3832-3844. doi: 10.1523/JNEUROSCI.0881-18.2019
Fresia P, Antelo V, Salazar C, Giménez M, D'Alessandro B, Afshinnekoo E, Mason C, Gonnet GH, Iraola G. Urban metagenomics uncover antibiotic resistance reservoirs in coastal beach and sewage waters. Microbiome. 2019 Feb 28;7(1):35. doi: 10.1186/s40168-019-0648-z
Robello C, Maldonado DP, Hevia A, Hoashi M, Frattaroli P, Montacutti V, Heguy A, Dolgalev I, Mojica M, Iraola G, Dominguez-Bello MG. The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole. PLoS One. 2019 Feb 26;14(2):e0212593. doi: 10.1371/journal.pone.0212593
Pita S, Díaz-Viraqué F, Iraola G, Robello C. The Tritryps Comparative Repeatome: Insights on Repetitive Element Evolution in Trypanosomatid Pathogens. Genome Biol Evol. 2019 Feb 1;11(2):546-551. doi: 10.1093/gbe/evz017
Turner KJ, Hoyle J, Valdivia LE, Cerveny KL, Hart W, Mangoli M, Geisler R, Rees M, Houart C, Poole RJ, Wilson SW, Gestri G. Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 2019 Jan 29;14(1):e0211073. doi: 10.1371/journal.pone.0211073
Ahumada-Castro U, Silva-Pavez E, Lovy A, Pardo E, Molgό J, Cárdenas C. MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Autophagy. 2019 Feb;15(2):358-361. doi: 10.1080/15548627.2018.1537769
Arrázola MS, Andraini T, Szelechowski M, Mouledous L, Arnauné-Pelloquin L, Davezac N, Belenguer P, Rampon C, Miquel MC. Mitochondria in Developmental and Adult Neurogenesis. Neurotox Res. 2019 Aug;36(2):257-267. doi: 10.1007/s12640-018-9942-y
2018
Antelo V, Salazar C, Martínez A, D'Alessandro B, Castro M, Betancor L, Barcala MV, Míguez D, Gonnet GH, Iraola G. First Release of the Bacterial Biobank of the Urban Environment (BBUE). Microbiol Resour Announc. 2018 Oct 25;7(16):e01201-18. doi: 10.1128/MRA.01201-18
Troncoso-Escudero P, Parra A, Nassif M, Vidal RL. Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease. Front Neurol. 2018 Oct 15;9:860. doi: 10.3389/fneur.2018.00860
Hernández DE, Salvadores NA, Moya-Alvarado G, Catalán RJ, Bronfman FC, Court FA. Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis. J Cell Sci. 2018 Nov 19;131(22):jcs214684. doi: 10.1242/jcs.214684
Fuentes R, Letelier J, Tajer B, Valdivia LE, Mullins MC. Fishing forward and reverse: Advances in zebrafish phenomics. Mech Dev. 2018 Dec;154:296-308. doi: 10.1016/j.mod.2018.08.007
Müller M, Ahumada-Castro U, Sanhueza M, Gonzalez-Billault C, Court FA, Cárdenas C. Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging. Front Neurosci. 2018 Jul 13;12:470. doi: 10.3389/fnins.2018.00470
Medinas DB, Rozas P, Martínez Traub F, Woehlbier U, Brown RH, Bosco DA, Hetz C. Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8209-8214. doi: 10.1073/pnas.1801109115
Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C. IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nat Cell Biol. 2018 Aug;20(8):942-953. doi: 10.1038/s41556-018-0141-0
Martínez G, Khatiwada S, Costa-Mattioli M, Hetz C. ER Proteostasis Control of Neuronal Physiology and Synaptic Function. Trends Neurosci. 2018 Sep;41(9):610-624. doi: 10.1016/j.tins.2018.05.009
Ferrés I, Iraola G. MLSTar: automatic multilocus sequence typing of bacterial genomes in R. PeerJ. 2018 Jun 15;6:e5098. doi: 10.7717/peerj.5098
Gonzalez D, Rebolledo DL, Correa LM, Court FA, Cerpa W, Lipson KE, van Zundert B, Brandan E. The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Hum Mol Genet. 2018 Aug 15;27(16):2913-2926. doi: 10.1093/hmg/ddy204.
Yıldırım Y, Ouriachi T, Woehlbier U, Ouahioune W, Balkan M, Malik S, Tolun A. Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility. Eur J Hum Genet. 2018 Jun;26(6):876-885. doi: 10.1038/s41431-018-0121-7
Catenaccio A, Court FA. Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis. Methods Mol Biol. 2018;1739:329-337. doi: 10.1007/978-1-4939-7649-2_21
De Gregorio C, Díaz P, López-Leal R, Manque P, Court FA. Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs. Methods Mol Biol. 2018;1739:299-315. doi: 10.1007/978-1-4939-7649-2_19
López-Leal R, Diaz P, Court FA. In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia. Methods Mol Biol. 2018;1739:255-267. doi: 10.1007/978-1-4939-7649-2_16
Valenzuela V, Nassif M, Hetz C. Unraveling the role of motoneuron autophagy in ALS. Autophagy. 2018;14(4):733-737. doi: 10.1080/15548627.2018.1432327
Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, Rush T, Vizzuso D, Court FA, Bachi A, Wrabetz L, Feltri ML. A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies. J Neurochem. 2018 May;145(3):245-257. doi: 10.1111/jnc.14295
SanMartin CD, Henriquez M, Chacon C, Ponce DP, Salech F, Rogers NK, Behrens MI. Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients. Curr Alzheimer Res. 2018;15(6):561-569. doi: 10.2174/1567205015666171227154636.
Krasnow AM, Ford MC, Valdivia LE, Wilson SW, Attwell D. Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nat Neurosci. 2018 Jan;21(1):24-28. doi: 10.1038/s41593-017-0031-y
Yıldız Bölükbaşı E, Mumtaz S, Afzal M, Woehlbier U, Malik S, Tolun A. Homozygous mutation in CEP19, a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly. J Med Genet. 2018 Mar;55(3):189-197. doi: 10.1136/jmedgenet-2017-104758
2017
Catenaccio A, Llavero Hurtado M, Diaz P, Lamont DJ, Wishart TM, Court FA. Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. Cell Death Dis. 2017 Nov 9;8(11):e3166. doi: 10.1038/cddis.2017.489
Bargsted L, Medinas DB, Martínez Traub F, Rozas P, Muñoz N, Nassif M, Jerez C, Catenaccio A, Court FA, Hetz C, Matus S. Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model. Sci Rep. 2017 Oct 27;7(1):14266. doi: 10.1038/s41598-017-14399-5
Mukherjee A, Morales-Scheihing D, Salvadores N, Moreno-Gonzalez I, Gonzalez C, Taylor-Presse K, Mendez N, Shahnawaz M, Gaber AO, Sabek OM, Fraga DW, Soto C. Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. J Exp Med. 2017 Sep 4;214(9):2591-2610. doi: 10.1084/jem.20161134
Salvadores N, Searcy JL, Holland PR, Horsburgh K. Chronic cerebral hypoperfusion alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and haemorrhages in Tg-SwDI mice. Clin Sci (Lond). 2017 Jul 24;131(16):2109-2123. doi: 10.1042/CS20170962
Balboa E, Castro J, Pinochet MJ, Cancino GI, Matías N, Sáez PJ, Martínez A, Álvarez AR, Garcia-Ruiz C, Fernandez-Checa JC, Zanlungo S. MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content. Redox Biol. 2017 Aug;12:274-284. doi: 10.1016/j.redox.2017.02.024
2016
López-Leal R, Alvarez J, Court FA. Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium? Cytoskeleton (Hoboken). 2016 Oct;73(10):629-639. doi: 10.1002/cm.21319
Schwann Cell and Axon: An Interlaced Unit-From Action Potential to Phenotype Expression. Court FA, Alvarez J. Adv Exp Med Biol. 2016;949:183-201. doi: 10.1007/978-3-319-40764-7_9
Oñate M, Court FA, Hetz C. Bursting the unfolded protein response accelerates axonal regeneration. Neural Regen Res. 2016 Jun;11(6):892-3. doi: 10.4103/1673- 5374.184453
Valenzuela V, Oñate M, Hetz C, Court FA. Injury to the nervous system: A look into the ER. Brain Res. 2016 Oct 1;1648(Pt B):617-625. doi: 10.1016/j.brainres.2016.04.053. Epub 2016 Apr 23
Calvo M, Richards N, Schmid AB, Barroso A, Zhu L, Ivulic D, Zhu N, Anwandter P, Bhat MA, Court FA, McMahon SB, Bennett DL. Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury. Elife. 2016 Apr 19;5:e12661. doi: 10.7554/eLife.12661